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Special Issue: Analysis of Biological Samples for Chemical Warfare Agents

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JANUARY/FEBRUARY 2008

 

Editorial, John R. Barr

An Overview of Biological Markers of Exposure to Chemical Warfare Agents,
Robin M. Black

Analysis of Urinary Metabolites of Sulfur Mustard in Two Individuals after Accidental Exposure,
John R. Barr, Carrie L. Pierce, J. Richard Smith, Benedict R. Capacio, Adrian R. Woolfitt, Maria I. Solano, Joe V. Wooten, Sharon W. Lemire, Jerry D. Thomas, Doris H. Ash, and David L. Ashley

Analysis for Plasma Protein Biomarkers Following an Accidental Human Exposure to Sulfur Mustard,
J. Richard Smith, Benedict R. Capacio, William D. Korte, Adrian R. Woolfitt, and John R. Barr

Retrospective Detection of Sulfur Mustard Exposure by Mass Spectrometric Analysis of Adducts to Albumin and Hemoglobin: An In Vivo Study,
D. Noort, A. Fidder, C.E.A.M. Degenhardt-Langelaan, and A.G. Hulst

Improvements in the Methodology of Monitoring Sulfur Mustard Exposure by Gas Chromatography–Mass Spectrometry Analysis of Cleaved and Derivatized Blood Protein Adducts,
Richard J. Lawrence, J. Richard Smith, Brian L. Boyd, and Benedict R. Capacio

Gas Chromatographic–Mass Spectrometric Analysis of Sulfur Mustard-Plasma Protein Adducts: Validation and Use in a Rat Inhalation Model,
Benedict R. Capacio, J. Richard Smith, Richard J. Lawrence, Brian L. Boyd, Alicia M. Witriol, Michele L. Conti, Jennifer L. Collins, and Alfred M. Sciuto

Multianalyte Quantification of Five Sesqui- and Ethyl Ether Oxy-Mustard Metabolites in Human Urine by Liquid Chromatography–Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry,
Doris H. Ash, Sharon W. Lemire, Sara C. McGrath, Lisa G. McWilliams, and John R. Barr

Development of a Liquid Chromatography–Multiple Reaction Monitoring Procedure for Concurrent Verification of Exposure to Different Forms of Mustard Agents,
Thong-Hiang Yeo, Mer-Lin Ho, and Weng-Keong Loke

Gas Chromatography–Tandem Mass Spectrometry Analysis of Red Blood Cells from Göttingen Minipig® following Whole-Body Vapor Exposure to VX,
C.E. Byers, J.M. McGuire, S.W. Hulet, D.C. Burnett, B.I. Gaviola, E.M. Jakubowski, and S.A. Thomson

A Rapid and Sensitive Technique for Assessing Exposure to VX via GC–MS–MS Analysis,
Jeffrey M. McGuire, Christopher E. Byers, Stanley W. Hulet, Edward M. Jakubowski, and Sandra A. Thomson

Quantification of Nerve Agent VX-Butyrylcholinesterase Adduct Biomarker from an Accidental Exposure,
Maria I. Solano, Jerry Thomas, James T. Taylor, Jeffrey M. McGuire, Edward. M. Jakubowski, Sandra A. Thomson, Vincent L. Maggio, Kerry E. Holland, J. Richard Smith, Benedict Capacio, Adrian R. Woolfitt, David L. Ashley, and John R. Barr

Determination of VX-G Analogue in Red Blood Cells via Gas Chromatography–Tandem Mass Spectrometry Following an Accidental Exposure to VX,
Jeffrey M. McGuire, James T. Taylor, Christopher E. Byers, Edward M. Jakubowski, and Sandra A. Thomson

Quantification of Sarin and Cyclosarin Metabolites Isopropyl Methylphosphonic Acid and Cyclohexyl Methylphosphonic Acid in Minipig Plasma Using Isotope-Dilution and Liquid Chromatography–Time of Flight Mass Spectrometry,
R.A. Evans, E.M. Jakubowski, W.T. Muse, K. Matson, S.W. Hulet, R.J. Mioduszewski, S.A. Thomson, A.L. Totura, J.A. Renner, and C.L. Crouse

A Gas Chromatographic–Mass Spectrometric Approach to Examining Stereoselective Interaction of Human Serum Proteins with Soman,
David T. Yeung, J. Richard Smith, Richard E. Sweeney, David E. Lenz, and Douglas M. Cerasoli

Validation and Application of a Gas Chromatography–Mass Spectrometry Method for Determining Soman Concentration in Rat Plasma Following Low-Level Vapor Exposure,
Julie A. Renner, Paul A. Dabisch, Ronald A. Evans, Jeffrey M. McGuire, Allison L. Totura, Edward M. Jakubowski, and Sandra A. Thomson

3-Chlorotyrosine and 3,5-Dichlorotyrosine as Biomarkers of Respiratory Tract Exposure to Chlorine Gas,
Mark A. Sochaski, Annie M. Jarabek, John Murphy, and Melvin E. Andersen

A Rapid, Cost-Effective Method for Analyzing Organophosphorus Pesticide Metabolites in Human Urine for Counter-Terrorism Response,
Gayanga Weerasekera, Kimberly D. Smith, Larry L. Needham, and Dana B. Barr

Modifications to the Organophosphorus Nerve Agent-Butyrylcholinesterase Adduct Refluoridation Method for Retrospective Analysis of Nerve Agent Exposures,
Kerry E. Holland, Maria I. Solano, Rudolph C. Johnson, Vincent L. Maggio, and John R. Barr

Verification of Exposure to Cholinesterases Inhibitors: Generic Detection of Schedule 1 Nerve Agent Adducts to Human Butyrylcholinesterase,
M.J. van der Schans, A. Fidder, D. van Oeveren, A.G. Hulst, and D. Noort

 


Special Issue: Society of Forensic Toxicologists, Inc.
Guest Editor: Sarah Kerrigan

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OCTOBER 2007

423 SOFT President’s Letter

424 Prevalence and Disposition of Drugs of Abuse and Opioid Treatment Drugs in Oral Fluid, Edward J. Cone, Joe Clarke, and Lolita Tsanaclis

434 Rapid Quantification of Urinary Oxycodone and Oxymorphone Using Fast Gas Chromatography–Mass Spectrometry, Scott G. McKinley, J. Jacob Snyder, Eric Welsh, Charles M. Kazarian, Matthew H. Jamerson, and Kevin L. Klette

442 Achieving Proposed Federal Concentrations using Reduced Specimen Volume for the Extraction of Amphetamines from Oral Fluid, Christine Moore, Cynthia Coulter, and Katherine Crompton

447 Stable Isotopes as Valid Components for Identification of Drugs in Biological Specimens, Buddha D. Paul, Justin M. Holler, Timothy P. Lyons, and Marilyn R. Past

453 Quantitative Analysis of Naltrexone and 6β-Naltrexol in Human, Rat, and Rabbit Plasma by Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry with Application to the Pharmacokinetics of Depotrex® in Rabbits, Matthew H. Slawson, Meng Chen, David E. Moody, Sandra D. Comer, Elie S. Nuwayser, Wenfang B. Fang, and Rodger L. Foltz

462 Cocaine and Metabolites Urinary Excretion after Controlled Smoked Administration, Marilyn A. Huestis, W. David Darwin, Eric Shimomura, Shairose A. Lalani, Daniel V. Trinidad, Amanda J. Jenkins, Edward J. Cone, Aaron J. Jacobs, Michael L. Smith, and Buddha D. Paul

469 Vitreous Fluid Quantification of Opiates, Cocaine, and Benzoylecgonine: Comparison of Calibration Curves in Both Blood and Vitreous Matrices with Corresponding Concentrations in Blood, Heather M. Antonides, Elizabeth R. Kiely, and Laureen J. Marinetti

477 Simultaneous GC–EI-MS Determination of D9-Tetrahydrocannabinol, 11-Hydroxy-D9-Tetrahydrocannabinol, and 11-nor-9-Carboxy-D9-Tetrahydrocannabinol in Human Urine Following Tandem Enzyme–Alkaline Hydrolysis, Tsadik T. Abraham, Ross H. Lowe, Stephane O. Pirnay, William D. Darwin, and Marilyn A. Huestis

486 Urine pH: the Effects of Time and Temperature after Collection, Janine D. Cook, Kathy A. Strauss, Yale H. Caplan, Charles P. LoDico, and Donna M. Bush

497 Liquid Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Analysis of Multiple Hallucinogens, Chlorpheniramine, Ketamine, Ritalinic Acid, and Metabolites in Urine, Maria del Mar Ramirez Fernandez, Marleen Laloup, Michelle Wood, Gert De Boeck, Manuel Lopez-Rivadulla, Pierre Wallemacq, and Nele Samyn

505 LC–(TOF) MS Analysis of Benzodiazepines in Urine from Alleged Victims of Drug-Facilitated Sexual Assault, Mahmoud A. ElSohly, Waseem Gul, Timothy P. Murphy, Bharathi Avula, and Ikhlas A. Khan

515 Direct-Injection Mass Spectrometric Method for the Rapid Identification of Fentanyl and Norfentanyl in Postmortem Urine of Six Drug-Overdose Cases, Cody J. Peer, Diaa M. Shakleya, Islam R. Younis, James C. Kraner, and Patrick S. Callery

522 CASE REPORT: Loss of Ethanol from Vitreous Humor in Drowning Deaths, Peter P. Singer, Graham R. Jones, Russell Lewis, and Robert Johnson

526 CASE REPORT: The Tissue Distribution of Fluoride in a Fatal Case of Self-Poisoning, María A. Martínez, Salomé Ballesteros, Francisco J. Piga, Carolina Sánchez de la Torre, and Carlos Cubero

534 CASE REPORT: A Fatality from Sevoflurane Abuse, Barry Levine, Dawn Cox, Rebecca A. Jufer Phipps, Ling Li, Aaron Jacobs, and David Fowler

537 CASE REPORT: Distribution of Phencyclidine into Vitreous Humor, Dawn Cox, Rebecca A. Jufer Phipps, Barry Levine, Aaron Jacobs, and David Fowler

540 CASE REPORT: Assessing Free and Total Morphine following Heroin Overdose when Complicated by the Presence of Toxic Amitriptyline Levels, Joseph Avella, Michael Katz, and Michael Lehrer


 

Special Issue: Society of Forensic Toxicologists, Inc.
Guest Editor: Marc A. LeBeau

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October 2006

SOFT President’s Letter

External Contamination of Hair with Cocaine: Evaluation of External Cocaine Contamination and Development of Performance Testing Materials,
Peter Stout, Jeri Ropero-Miller, Michael Baylor, and John Mitchell

Major and Minor Metabolites of Cocaine in Human Plasma following Controlled Subcutaneous Cocaine Administration,
Erin A Kolbrich, Allan J. Barnes, David A. Gorelick, Susan J. Boyd, Edward J. Cone, and Marilyn A. Huestis

Cyanide and Thiocyanate in Human Saliva by Gas Chromatography–Mass Spectrometry,
Buddha Paul and Michael Smith

Determination of Propoxyphene in Oral Fluid,
Sumandeep Rana, Christine Moore, Michael Vincent, Cynthia Coulter, Alpana Agrawal, and James Soares

The Determination of Morphine in the Larvae of Calliphora stygia using Flow Injection Analysis and HPLC with Chemiluminescence Detection,
Joshua A. Gunn, Cara Shelley, Simon W. Lewis, Tes Toop, and Melanie Archer

LC–MS-(TOF) Analysis Method for Benzodiazepines in Urine Samples from Alleged Drug-Facilitated Sexual Assault Victims,
Mahmoud A. ElSohly, Waseem Gul, Kareem M. ElSohly, Bharathi Avula, and Ikhlas A. Khan

Applications of Ion Mobility Spectrometry (IMS) to the Analysis of gamma-Hydroxybutyrate and gamma-Hydroxyvalerate in Toxicological Matrices,
Jennifer Mercer, Diaa Shakleya, and Suzanne Bell

Distribution of Methylenedioxymethamphetamine (MDMA) and Methylenedioxyamphetamine (MDA) in Postmortem and Antemortem Specimens,
Ray H. Liu, Hsiu-Chuan Liu, and Dong-Liang Lin

Occupational Exposure to Methamphetamine in Workers Preparing Training Aids for Drug Detection Dogs,
P.R. Stout, C.K. Horn, K.L. Klette, and J. Given

Rapid Analysis of Benzoylecgonine in Urine By Fast Gas Chromatography– Mass Spectrometry,
Robert W. Romberg, Matthew H. Jamerson, and Kevin L. Klette

Validation of a Headspace GC Method for the Analysis of a Pyrolytic Product of Methamphetamine in Urine,
Diaa M. Shakleya, James C. Kraner, David J. Clay, Patrick S. Callery, and Suzanne Bell

Selection and Optimization of Hydrolysis Conditions for the Quantification of Urinary Metabolites of MDMA,
Stephane O. Pirnay, Tsadik T. Abraham, Ross H. Lowe, and Marilyn A. Huestis

Incomplete Recovery of Prescription Opioids in Urine using Enzymatic Hydrolysis of Glucuronide Metabolites,
Ping Wang, Judith A. Stone, Katherine H. Chen, Susan F. Gross, Christine Haller, and Alan H.B. Wu

A First Look at Duloxetine (Cymbalta®) in a Postmortem Laboratory,
D. Anderson, S. Reed, J. Lintemoor, S. Kegler, S. DeQuintana, M. Sandberg, and J. Muto

Performance Evaluation of Thermal Desorption System (TDS) for Detection of Basic Drugs in Forensic Samples by GC–MS,
Joseph Crifasi, Michael Bruder, Christopher Long, and Kimberly Janssen

Liquid Chromatography–Tandem Mass Spectrometry (LC–ESI-MS–MS) for the Determination of Colchicine in Postmortem Body Fluids. Case Report of Two Fatalities and Review of the Literature,
Marjorie Chèze, Marc Deveaux, and Gilbert Pépin

Topiramate-Positive Death-Investigation and Impaired-Driving Cases in Washington State,
Ann Marie Gordon and Barry K. Logan

Fentanyl-Related Deaths in Ontario, Canada: Toxicological Findings and Circumstances of Death in 112 Cases (2002–2004),
Teri Martin, Karen Woodall, and Barry McLellan

TECHNICAL NOTE: Caffeine Content of Decaffeinated Coffee,
Rachel R. McCusker, Brian Fuehrlein, Bruce A. Goldberger, Mark S. Gold, and Edward J. Cone

TECHNICAL NOTE: Recovery of Drugs of Abuse from the Immunalysis Quantisal™ Oral Fluid Collection Device,
Oscar Quintela, Dennis J. Crouch, and David M. Andrenyak

TECHNICAL NOTE: Validation of an ELISA Method for Screening Methadone in Postmortem Blood,
Matthew Juhascik, Steven Habbel, William Barron, and George Behonick

SHORT COMMUNICATION: Multi-Element Screening by ICP-MS of Two Specimens of Napoleon’s Hair,
Pascal Kintz, Morgane Ginet, and Vincent Cirimele

CASE REPORT: Investigation of a Fatality Due to Diesel Fuel No. 2 Ingestion,
María Martínez and Salomé Ballesteros

CASE REPORT: Distribution of Ether in Two Postmortem Cases,
Dawn Cox, Rebecca DeRienz, Rebecca A. Jufer Phipps, Barry Levine, Aaron Jacobs, and David Fowler

CASE REPORT: A Motor Vehicle Aaccident Fatality Involving the Inhalation of 1,1-Difluoroethane (DFE, “Dust Off”),
Timothy Hahn, Joseph Avella, and Michael Lehrer

LETTER TO THE EDITOR: Phencyclidine Detection in Nails,
Amanda J. Jenkins and David A. Engelhart

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Special Issue: Society of Forensic Toxicologists, Inc.
Guest Editor: Jeri D. Ropero-Miller

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October 2005

Letter from the President of SOFT

Pharmacogenomics as Molecular Autopsy for Forensic Toxicology: Genotyping Cytochrome P450 3A4*1B and 3A5*3 for 25 Fentanyl Cases
Ming Jin, Susan B. Gock, Paul J. Jannetto, Jeffrey M. Jentzen, and Steven H. Wong

Investigation of an LC–MS–MS (Qtrap®) Method for the Rapid Screening and Identification of Drugs in Postmortem Toxicology Whole Blood Samples,
George L. Herrin, H. Horton McCurdy, and William H. Wall

Passive Cannabis Smoke Exposure and Oral Fluid Testing. II. Two Studies of Extreme Cannabis Smoke Exposure in a Motor Vehicle,
R. Sam Niedbala, Keith W. Kardos, Dean F. Fritch, Kenneth P. Kunsman, Kristen A. Blum, Gregory A. Newland, Joe Waga, Lisa Kurtz, Matth Bronsgeest, and Edward J. Cone

Validation of a Liquid Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Determination of 26 Benzodiazepines and Metabolites, Zolpidem and Zopiclone, in Blood, Urine, and Hair,
Marleen Laloup, Maria del Mar Ramirez Fernandez, Gert De Boeck, Michelle Wood, Viviane Maes, and Nele Samyn

Urine pH, Container Composition, and Exposure Time Influence Adsorptive Loss of 11-nor-Δ9-Tetrahydrocannabinol-9-Carboxylic Acid,
Matthew H. Jamerson, Joseph J. McCue, and Kevin L. Klette

Usefulness of Roadside Urine Drug Screening in Drivers Suspected of Driving Under the Influence of Drugs,
Elke Raes and Alain G. Verstraete

The Identification of Mivacurium and Metabolites in Biological Samples,
Madeline A. Montgomery, Marc A. LeBeau, Mark L. Miller, and Rebecca A. Jufer

Investigation of Fatalities Due to Acute Gasoline Poisoning,
María A. Martínez and Salomé Ballesteros

Quantitative and Isomeric Determination of Amphetamine and Methamphetamine from Urine using a Nonprotic Elution Solvent and R(–)-a-Methoxy-a-Trifluoromethylphenylacetic Acid Chloride Derivatization,
Justin M. Holler, Shawn P. Vorce, Thomas Z. Bosy, and Aaron Jacobs

Spectrophotometric Detection of Iodide and Chromic (III) in Urine after Oxidation to Iodine and Chromate (VI),
Buddha D. Paul and Aaron Jacobs

Rapid Quantification of Urinary 11-nor-Δ9-Tetrahydrocannabinol-9-Carboxylic Acid using Fast Gas Chromatography–Mass Spectrometry,
Matthew H. Jamerson, Robert M. Welton, Cynthia L. Morris-Kukoski, and Kevin L. Klette

Rapid Simultaneous Determination of Amphetamine, Methamphetamine, 3,4-Methylenedioxyamphetamine, 3,4-Methylenedioxymethamphetamine, and 3,4-Methylenedioxyethylamphetamine in Urine by Fast Gas Chromatography– Mass Spectrometry,
Kevin L. Klette, Matthew H. Jamerson, Cynthia L. Morris-Kukoski, Aaron R. Kettle, and J. Jacob Snyder

Evaluation of the DRI® Oxycodone Immunoassay for the Detection of Oxycodone in Urine,
Ronald C. Backer, Joseph R. Monforte, and Alphonse Poklis

Comparison of Cozart® Microplate ELISA and GC–MS Detection of Methadone and Metabolites in Human Hair,
Gail Cooper, Lisa Wilson, Claire Reid, Dene Baldwin, Chris Hand, and Vina Spiehler

Quantitation of R-(–)- and S-(+)-Amphetamine in Hair and Blood by Gas Chromatography–Mass Spectrometry: An Application to Compliance Monitoring in Adult-Attention Deficit Hyperactivity Disorder Treatment,
Ingrid Nystrom, Tomas Trygg, Per Woxler, Johan Ahlner, and Robert Kronstrand

Usefulness of Salivary trans-3'-Hydroxycotinine Concentration and trans-3'-Hydroxycotinine/Cotinine Ratio as Biomarkers of Cigarette Smoke in Pregnant Women,
Insook Kim, Abraham Wtsadik, Robin E. Choo, Hendree E. Jones, and Marilyn A. Huestis

Multiple Aspects of Hair Analysis for Opiates: Methodology, Clinical and Workplace Populations, and Codeine and Poppy Seed Ingestion,
Virginia Hill, Thomas Cairns, Chen-Chih Cheng, and Michael Schaffer

TECHNICAL NOTE: Direct Analysis of Opiates in Urine by Liquid Chromatography–Tandem Mass Spectrometry,
Leslie E. Edinboro, Ronald C. Backer, and Alphonse Poklis

TECHNICAL NOTE: A Rapid HPLC Procedure for Analysis of Analgesic Pharmaceutical Mixtures for Quality Assurance and Drug Diversion Testing,
Carl E. Wolf and Alphonse Poklis

TECHNICAL NOTE: Methylation of 3,4-Methylenedioxymethamphetamine in Formalin-Fixed Human Liver Tissue,
Diaa M. Shakleya, James C. Kraner, James A. Kaplan, and Patrick S. Callery

TECHNICAL NOTE: Performance Characteristics of 7-Aminoflunitrazepam Specific Enzyme-Linked Immunosorbent Assays,
Dong-Liang Lin, Rea-Ming Yin, Cheng-Hsing Chen, Ya-Lei Chen, and Ray H. Liu

TECHNICAL NOTE: Detection of Cannabis Use in Drivers with the Drugwipe Device and by GC–MS after Intercept Device Collection,
Pascal Kintz, Werner Bernhard, Marion Villain, Martina Gasser, Beat Aebi, and Vincent Cirimele

TECHNICAL NOTE: Sample Liquid Chromatographic Method for the Rapid and Simultaneous Determination of Propoxur and its Major Metabolite Isopropoxy Phenol in Rat Blood and Urine Using Solid-Phase Extraction,
Ramagiri Suma, R.K. Sarin, P.K. Saiprakash, and Sistla Ramakrishna

CASE REPORT: Percutaneous Absorption and Distribution of Methanol in a Homicide,
Joseph Avella, Edward Briglia, Gwendolyn Harleman, and Michael Lehrer

CASE REPORT: Over-the-Counter Cold Medications—Postmortem Findings in Infants and the Relationship to Cause of Death,
Laureen Marinetti, Lee Lehman, Brian Casto, Kent Harshberger, Piotr Kubiczek, and James Davis

CASE REPORT: Apparent Suicidal Carbon Monoxide Poisonings with Concomitant Prescription Drug Overdoses, Avneesh Gupta, Melissa A. Pasquale-Styles,
Bradford R. Hepler, Daniel S. Isenschmid, and Carl J. Schmidt

CASE REPORT: Tissue Distribution of Loperamide and N-Desmethylloperamide Following a Fatal Overdose,
Jason Sklerov, Barry Levine, Karla A. Moore, Carol Allan, and David Fowler

CASE REPORT: Fatal Seizures Due to Potential Herb-Drug Interactions with Ginkgo Biloba,
Thomas Kupiec and Vishnu Raj

CASE REPORT: Determination of l-Methamphetamine: A Case History,
John F. Wyman and John T. Cody

CASE REPORT: Elevated Postmortem Ethanol Concentrations in an Insulin-Dependent Diabetic,
Ines B. Collison

LETTER TO THE EDITOR: Detection of Smoked Cocaine Marker (Anhydroecgonine Methylester) in Nails,
C. Ragoucy-Sengler and P. Kintz

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Special Issue: 2004 SOFT–TIAFT Meeting Papers
Guest Editor: Marc LeBeau

JULY/AUGUST 2005
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Ethyl Sulfate: A Metabolite of Ethanol in Humans and a Potential Biomarker of Acute Alcohol Intake,
A. Helander and O. Beck

Papain: A Novel Urine Adulterant,
D.L. Burrows, A. Nicolaides, P.J. Rice, M. Dufforc, D.A. Johnson, and K.E. Ferslew

MDMA and MDA Concentrations in Antemortem and Postmortem Specimens in Fatalities Following Hospital Admission,
S.P. Elliott

GC–MS Quantitation of Codeine, Morphine, 6-Acetylmorphine, Hydrocodone, Hydromorphone, Oxycodone, and Oxymorphone in Blood,
R. Meatherall

Determination of Furosemide in Whole Blood Using SPE and GC–EI-MS,
C. Margalho, D. de Boer, E. Gallardo, M. Barroso, and D.N. Vieira

Evaluation of Ketamine Abuse Using Hair Analysis: Concentration Trends in a Singapore Population,
H.S. Leong, N.L. Tan, C.P. Lui, and T.K. Lee

Hair Analysis: The Requirement for Effective Wash Procedures and Effects of Drug Concentration and Hair Porosity in Contamination and Decontamination,
M. Schaffer, V. Hill, and T. Cairns

Assessment of Driving Capability Through the Use of Clinical and Psychomotor Tests in Relation to Blood Cannabinoids Levels Following Oral Administration of 20 mg Dronabinol or Cannabis Decoction Made with 20 or 60 mg Δ9-THC,
A. Ménétrey, M. Augsburger, B. Favrat, M.A. Pin, L.E. Rothuizen, M. Appenzeller, T. Buclin, P. Mangin, and C. Giroud

Amphetamine Binding to Synthetic Melanin and Scatchard Analysis of Binding Data,
L. Gautam, K.S. Scott, and M.D. Cole

Opiate Concentrations in Hair from Subjects in a Controlled Heroin-Maintenance Program and from Opiate-Associated Fatalities,
F. Musshoff, K. Lachenmeier, H. Wollersen, D. Lichtermann, and B. Madea

The Identification of a Chlorinated MDMA,
V. Maresova, J. Hampl, Z. Chundela, F. Zrcek, M. Polasek, and J. Chadt

TECHNICAL NOTE: Comparison of the Sensitivity and Specificity of Six Immunoassays for the Detection of Amphetamines in Urine,
A.G. Verstraete and F. Vander Heyden

TECHNICAL NOTE: Comparative Alcohol Concentrations in Blood and Vitreous Fluid With Illustrative Case Studies,
D. Honey, C. Caylor, R. Luthi, and S. Kerrigan

TECHNICAL NOTE: Gas Chromatography–High-Resolution Mass Spectrometric Method for Determination of Methamphetamine and Its Major Metabolite Amphetamine in Human Hair,
J.Y. Kim, S.I. Suh, M.K. In, and B.C. Chung

TECHNICAL NOTE: Urinary Excretion Rates of Ketamine and Norketaine Following Therapeutic Ketamine Administration: Method and Detection Window Consideration,
P. Adamowicz and M. Kala

TECHNICAL NOTE: Determination of Strychnine in Human Blood using Solid-Phase Extraction and GC–EI-MS,
M. Barroso, E. Gallardo, C. Margalho, E. Marques, D.N. Vieira, and M. López-Rivadulla

TECHNICAL NOTE: An Automated Alcohol Dehydrogenase Method for Ethanol Quantification in Urine and Whole Blood,
L. Kristoffersen and A. Smith-Kielland

TECHNICAL NOTE: Evaluation of the Post-Rotational Nystagmus Test (PRN) in Determining Alcohol Intoxication,
M. Karlovs¹ek and Balaz¹ic

CASE REPORT: Fatality Due to Acute a-Methyltryptamine Intoxication,
D.M. Boland, W. Andollo, G.W. Hime, and W.L. Hearn

CASE REPORT: Distribution of GHB in Tissues and Fluids Following a Fatal Overdose,
S. Mazarr-Proo and S. Kerrigan

CASE REPORT: Postmortem Distribution of Tramadol, Amitriptyline, and Their Metabolites in a Suicidal Overdose,
N.D. Bynum, J.L. Poklis, M. Gaffney-Kraft, D. Garside, and J.D. Ropero-Miller

CASE REPORT: Case Studies of Postmortem Quetiapine: Therapeutic or Toxic Concentrations?
D. Parker and I. McIntyre

2004 SOFT–TIAFT Joint Meeting Abstracts

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September 2004 SOFT Issue
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Relationship of Δ9-Tetrahydrocannabinol Concentations in Oral Fluid and Plasma after Controlled Administration of Smoked Cannabis
Marilyn A. Huestis and Edward J. Cone

Development of an Analytical Approach to the Specimens Collected from Victims of Sexual Assault
Matthew Juhascik, Ngog Lan Le, Kimberly Tomlinson, Christine Moore, R.E. Gaensslen, and Adam Negrusz

A General Screening and Confirmation Approach to the Analysis of Designer Tryptamines and Phenethylamines in Blood and Urine Using GC–EI-MS and HPLC–Electrospray-MS
Shawn P. Vorce and Jason H. Sklerov

Deposition Characteristics of Methamphetamine and Amphetamine in Fingernail Clippings and Hair Sections
Dong-Liang Lin, Rea-Ming Yin, Hsiu-Chuan Liu, Chung-Yi Wang, and Ray H. Liu

Sevoflurane Analysis in Serum by Headspace Gas Chromatography with Application to Various Biological Matrices
David L. Burrows, Andrea Nicolaides, Gretel C. Stephens, and Kenneth E. Ferslew

Urine Concentrations of Fentanyl and Norfentanyl During Application of Duragesic® Transdermal Patches
Alphonse Poklis and Ronald Backer

Urinary Analysis of Four Testosterone Metabolites and Pregnanediol by Gas Chromatography–Combustion–Isotope Ratio Mass Spectrometry after Oral Administrations of Testosterone
Arnaud Maõˆtre, Christophe Saudan, Patrice Mangin, and Martial Saugy

Metabolic Profile of Famprofazone Following Multidose Administration
April T. Rodriguez, Sandra Valtier, and John T. Cody

Cannabis (Marijuana) Contamination of United States and Foreign Paper Currency
Eric S. Lavins, Bethany D. Lavins, and Amanda J. Jenkins

A Liquid Chromatographic–Electrospray-Tandem Mass Spectrometric Method for Quantitation of Quetiapine in Human Plasma and Liver Microsomes: Application to a Study of In Vitro Metabolism
Shen-Nan Lin, Yan Chang, David E. Moody, and Rodger L. Foltz

Enantiomeric Separation and Quantitation of (±)-Amphetamine, (±)-Methamphetamine, (±)-MDA, (±)-MDMA, and (±)-MDEA in Urine Specimens by GC–EI-MS after Derivatization with (R)-(–) or (S)-(+)-a- Methoxy-a-(trifluoromethy)phenylacetyl Chloride (MTPA)
Buddha D. Paul, John Jemionek, David Lesser, Aaron Jacobs, and Douglas A. Searles

An Uncertainty Budget for the Measurement of Ethanol in Blood by Headspace Gas Chromatography
Jesper Kristiansen and Henning Willads Petersen

A Fatal Overdose of Cocaine Associated with Coingestion of Marijuana, Buprenorphine and Fluoxetine. Body Fluid and Tissue Distribution of Cocaine and Its Metabolites Determined by Hydrophilic Interaction Chromatography–Mass Spectrometry (HILIC–MS)
Christian Giroud, Katarzyna Michaud, Frank Sporkert, Chin Eap, Marc Augsburger, Pascal Cardinal, and Patrice Mangin

Lorazepam and Driving Impairment
Jayne E. Clarkson, Ann Marie Gordon, and Barry K. Logan

Suspected GHB Overdoses in the Emergency Department
Fiona J. Couper, Jayne E. Thatcher, and Barry K. Logan

Evaluation of the Triage PPY On-Site Testing Device for the Detection of Dextropropoxyphene in Urine
Alphonse Poklis, Justin L. Poklis, Lisa D. Tarnai, and Ronald C. Backer

Comparison of the Microgenics CEDIA® Heroin Metabolite (6-AM) and the Roche Abuscreen® ONLINE Opiate Immunoassays for the Detection of Heroin Use in Forensic Urine Samples
Justin M. Holler, Thomas Z. Bosy, Kevin L. Klette, Russel Wiegand, John Jemionek, and Aaron Jacobs

TECHNICAL NOTE: A High-Performance Liquid Chromatographic–Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometric Method for Determination of Risperidone and 9-Hydroxyrisperidone in Human Plasma
David E. Moody, John D. Laycock, Wei Huang, and Rodger L. Foltz

TECHNICAL NOTE: Validation of the Cozart® Microplate EIA for Cocaine and Metabolites in Oral Fluid, Gail Cooper
Lisa Wilson, Claire Reid, Dene Baldwin, Chris Hand, and Vina Spiehler

CASE REPORT: Two Cases Involving Clomipramine Intoxication
Joseph Avella, Michael Lehrer, Michael Katz, and Edward Minden

CASE REPORT: Hydroxycarbazepine Distribution in Three Postmortem Cases
Barry Levine, Deborah Green-Johnson, Karla A. Moore, and David R. Fowler

CASE REPORT: Addicted to Driving Under the Influence—a GHB/GBL Case Report
Fiona J. Couper and Barry K. Logan

CASE REPORT: Hair to Document Drug-Facilitated Crimes: Four Cases Involving Bromazepam
Marion Villain, Marjorie Ch`eze, Veronique Dumestre, Bertrand Ludes, and Pascal Kintz

CASE REPORT: Fatal Overdoses Associated with Quetiapine
Loralie J. Langman, Henry A. Kaliciak, and Sheila Carlyle

CASE REPORT: A Non-Fatal Case of Sodium Toxicity
Thomas C. Kupiec, John M. Goldenring, and Vishnu Raj

CASE REPORT: Postmortem Morphine Concentrations Following Use of a Continuous Infusion Pump
Sarah Kerrigan, Donna Honey, and Ginger Baker

CASE REPORT: Tissue Distribution of Molindone in a Multidrug Overdose
Dwight D. Flammia, Henry R. Bateman, Joseph J. Saady, and Erik D. Christensen

CASE REPORT: Metaxalone (Skelaxin®)-Related Death
Justin L. Poklis, Jeri D. Ropero-Miller, Diana Garside, and Ruth E. Winecker


JULY/AUGUST 2004
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Editorial, John R. Barr

Monitoring Sulfur Mustard Exposure by Gas Chromatography–Mass Spectrometry Analysis of Thiodiglycol Cleaved from Blood Proteins
B.R. Capacio, J.R. Smith, M.T. DeLion, D.R. Anderson, J.S. Graham, G.E. Platoff, and W.D. Korte

Procedure for Montoring Exposure to Sulfur Mustard Based on Modified Edman Degradation of Globin
D. Noort, A. Fidder, H.P. Benschop, L.P.A. de Jong, and J.R. Smith

Standard Operating Procedure for Immunuslotblot Assay for Analysis of DNA/Sulfur Mustard Adducts in Human Blood and Skin
G.P. van der Schans, R. Mars-Groenendijk, L.P.A. de Jong, H.P. Benschop, and D. Noort

Quantitation of Biomarkers of Exposure to Nitrogen Mustards in Urine from Rats Dosed with Nitrogen Mustards and from an Unexposed Human Population
S.W. Lemire, J.R. Barr, D.L. Ashley, C.T. Olson, and T.L. Hayes

Quantitation of the Sulfur Mustard Metabolites 1,1'-Sulfonylbis[2-(methylthio)ethane] and Thiodiglycol in Urine Using Isotope Dilution Gas Chromatography–Tandem Mass Spectrometry
A.E. Boyer, D. Ash, D.B. Barr, C.L. Young, W.J. Driskell, R.D. Whitehead, Jr., M. Ospina, K.E. Preston, A.R. Woolfitt, R.A. Martinez, L.A. Silks, and J.R. Barr

Retrospective Detection of Exposure to Sulfur Mustard: Improvements on an Assay for Liquid Chromatography–Tandem Mass Spectrometry Analysis of Albumin/Sulfur Mustard Adducts
D. Noort, A. Fidder, A.G. Hulst, A.R. Woolfitt, D. Ash, and J.R. Barr

A Rapid, Sensitive Method for the Quantitation of Specific Metabolites of Sulfur Mustard in Human Urine Using Isotope-Dilution Gas Chromatography–Mass Spectrometry
C.L. Young, D. Ash, W.J. Driskell, A.E. Boyer, R.A. Martinez, L.A. Silks, and J.R. Barr

Analysis of b-Lyase Metabolites of Sulfur Mustard in Urine by Electrospray Liquid Chromatography–Tandem Mass Spectrometry
R.W. Read and R.M. Black

Analysis of the Sulfur Mustard Metabolite 1,1'-Sulfonylbis[2-S-(N-acetylcysteinyl)ethane] in Urine by Negative Ion Electrospray Liquid Chromatography–Tandem Mass Spectrometry
R.W. Read and R.M. Black

Quantitation of Fluoride Ion Released Sarin in Red Blood Cell Samples by Gas Chromatography–Chemical Ionization Mass Spectrometry Using Isotope Dilution and Large-Volume Injection
E.M. Jakubowski, J.M. McGuire, R.A. Evans, J.L. Edwards, S.W. Hulet, B.J. Benton, J.S. Forster, D.C. Burnett, W.T. Muse, K. Matson, C.L. Crouse, R.J. Mioduszewski, and S.A. Thomson

Improvements of the Fluoride Reactivation Method for the Verification of Nerve Agent Exposure
C.E.A.M. Degenhardt, K. Pleijsier, M.J. van der Schans, J.P. Langenberg, K.E. Preston, M.I. Solano, V.L. Maggio, and J.R. Barr

Quantitation of Metabolites of the Nerve Agents Sarin, Soman, Cyclohexylsarin, VX, and Russian VX in Human Urine Using Isotope-Dilution Gas Chromatography–Mass Spectrometry
J.R. Barr, W.J. Driskell, L.S. Aston, and R.A. Martinez

Identification and Characterization of the Major Huperzine A Metabolite in Rat Blood
G.E. Garcia, R.P. Hicks, D. Skanchy, D.R. Moorad-Doctor, B.P. Doctor, and H.S. Ved

Gas Chromatographic–Mass Spectrometric Determination of British Anti-Lewisite in Plasma
C.E. Byers, E.R. Holloway, W.D. Korte, J.R. Smith, E.D. Clarkson, G.E. Platoff, and B.R. Capacio

TECHNICAL NOTE: Analysis of the Enantiomers of VX Using Normal-Phase Chiral Liquid Chromatography with Atmospheric Pressure Chemical Ionization-Mass Spectrometry
J.R. Smith


October SOFT issue 2003
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Urine Testing for Cocaine Abuse: Metabolic and Excretion Patterns Following Different Routes of Administration and Methods for Detection of False-Negative Results
Edward J. Cone, Angela Sampson-Cone, William D. Darwin, Marilyn A. Huestis, and Jonathan M. Oyler

Sensitivity, Specificity, and Efficiency in Detecting Opiate Use in Oral Fluid with the Cozart® Opiate Microplate EIA and GC–MS Following Controlled Codeine Administration
Allan J. Barnes, Insook Kim, Raf Schepers, Eric T. Moolchan, Lisa Wilson, Gail Cooper, Claire Reid, Chris Hand, and Marilyn A. Huestis

Cozart® RapiScan Oral Fluid Drug Testing System: An Evaluation of Sensitivity, Specificity, and Efficiency for Cocaine Detection Compared with ELISA and GC–MS Following Controlled Cocaine Administration
Erin A. Kolbrich, Insook Kim, Allan J. Barnes, Eric T. Moolchan, Lisa Wilson, Gail A. Cooper, Claire Reid, Dene Beldwin, Chris W. Hand, and Marilyn A. Huestis

Opiate Recidivism in a Drug-Treatment Program: Comparison of Hair and Urine Data
Bradley K. Charles, Jayme E. Day, Douglas E. Rollins, and Diana G. Wilkins

An Evaluation of Rapid Point-of-Collection Oral Fluid Drug-Testing Devices
J. Michael Walsh, Ron Flegel, Dennis J. Crouch, Leo Cangianelli, and Jakub Baudys

A Liquid Chromatographic–Tandem Mass Spectrometric Method for the Analysis of Serotonin and Related Indoles in Human Whole Blood
Jonathan P. Danaceau, George M. Anderson, William M. McMahon, and Dennis J. Crouch

Stability of Plasma Gamma-Hydroxybutyrate Determined by Gas Chromatography–Positive Ion Chemical Ionization-Mass Spectrometry
Meng Chen, David M. Andrenyak, David E. Moody, and Rodger L. Foltz

The Determination of Morphine in Urine and Oral Fluid Following Ingestion of Poppy Seeds
Timothy P. Rohrig and Christine Moore

Occupational Cocaine Exposure of Crime Laboratory Personnel Preparing Training Aids for a Military Working Dog Program
Jay M. Gehlhausen, Kevin L. Klette, Peter R. Stout, and JoAnn Given

LC–MS Analysis of 2-Oxo-3-Hydroxy LSD from Urine Using a Speedisk Positive Pressure Processor with Cerex PolyChrom CLIN II Columns
Carl K. Horn, Kevin L. Klette, and Peter R. Stout

Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronides in Urine by Liquid Chromatography–Mass Spectrometry
Robert Kronstrand, Tor Seldén, and Martin Josefsson

Performance Characteristics of Selected Immunoassays for Preliminary Test of 3,4-Methylenedioxymethamphetamine, Methamphetamine, and Related Drugs in Urine Specimens
Jui Hsu, Chiareiy Liu, C.P. Hsu, Wen-Ing Tsay, Jih-Heng Li, Dong-Liang Lin, and Ray H. Liu

Metabolic Profile of Amphetamine and Methamphetamine Following Administration of the Drug Famprofazine
Brandy Greenhill, Sandra Valtier, and John T. Cody

Amphetamine Enantiomer Excretion Profile Following Administration of Adderall
John T. Cody, Sandra Valtier, and Stephen L. Nelson

Postmortem Indentification and Quantitation of 2,5-Dimethoxy-4-n-propylthiophenethylamine Using GC–MSD and GC–NPD
Byron Curtis, Philip Kemp, Linda Harty, Chai Choi, and Dix Christensen

Fentanyl Misuse and Abuse: A Summary of 23 Postmortem Cases
James J. Kuhlman, Jr., Rebecca McCaulley, Tara J. Valouch, and George S. Behonick

Development of a Rapid and Sensitive Method for the Quantitation of Benzodiazepines in Calliphora vicina Larvae and Puparia by LC–MS–MS
M. Wood, M. Laloup, K. Pien, N. Samyn, M. Morris, R.A.A. Maes, E.A. de Bruijn, V. Maes, and G. De Boeck

TECHNICAL NOTE: Analysis of Fentanyl and Norfentanyl in Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry Using Electrospray Ionization
J. Day, M. Slawson, R.A. Lugo, and D. Wilkins

TECHNICAL NOTE: Stability of Ethanol in Postmortem Blood and Vitreous Humor in Long-Term Refrigerated Storage
Theresa Olsen and W. Lee Hearn

TECHNICAL NOTE: Caffeine Content of Specialty Coffees
Rachel R. McCusker, Bruce A. Goldberger, and Edward J. Cone

CASE REPORT: Fatal Cold Medication Intoxication in an Infant
Diane M. Boland, Joseph Rein, Emma O. Lew, and W. Lee Hearn

CASE REPORT: Buprenorphine in Drug-Facilitated Sexual Abuse: A Fatal Case Involving a 14-Year-Old Boy
Pascal Kintz, Marion Villain, Antoine Tracqui, Vincent Cirimele, and Bertrand Ludes

LETTER TO THE EDITOR: Evaluation of a Solid-Phase Extraction Method for Codeine and Morphine in Urine Using Cerex Polychrom™ Clin II Columns and the Speedisk™ 48 Pressure Processor at a High-Throughput Forensic Drug-Testing Laboratory
Melissa M. Churley, Timothy P. Lyons, Paul V. Robrandt, and Mark R. Bruins

 


October SOFT issue 2002
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Urine Testing for Cocaine Abuse: Metabolic and Excretion Patterns Following Different Routes of Administration and Methods for Detection of False-Negative Results
Edward J. Cone, Angela Sampson-Cone, William D. Darwin, Marilyn A. Huestis, and Jonathan M. Oyler

Sensitivity, Specificity, and Efficiency in Detecting Opiate Use in Oral Fluid with the Cozart® Opiate Microplate EIA and GC–MS Following Controlled Codeine Administration
Allan J. Barnes, Insook Kim, Raf Schepers, Eric T. Moolchan, Lisa Wilson, Gail Cooper, Claire Reid, Chris Hand, and Marilyn A. Huestis

Cozart® RapiScan Oral Fluid Drug Testing System: An Evaluation of Sensitivity, Specificity, and Efficiency for Cocaine Detection Compared with ELISA and GC–MS Following Controlled Cocaine Administration
Erin A. Kolbrich, Insook Kim, Allan J. Barnes, Eric T. Moolchan, Lisa Wilson, Gail A. Cooper, Claire Reid, Dene Beldwin, Chris W. Hand, and Marilyn A. Huestis

Opiate Recidivism in a Drug-Treatment Program: Comparison of Hair and Urine Data
Bradley K. Charles, Jayme E. Day, Douglas E. Rollins, and Diana G. Wilkins

An Evaluation of Rapid Point-of-Collection Oral Fluid Drug-Testing Devices
J. Michael Walsh, Ron Flegel, Dennis J. Crouch, Leo Cangianelli, and Jakub Baudys

A Liquid Chromatographic–Tandem Mass Spectrometric Method for the Analysis of Serotonin and Related Indoles in Human Whole Blood
Jonathan P. Danaceau, George M. Anderson, William M. McMahon, and Dennis J. Crouch

Stability of Plasma Gamma-Hydroxybutyrate Determined by Gas Chromatography–Positive Ion Chemical Ionization-Mass Spectrometry
Meng Chen, David M. Andrenyak, David E. Moody, and Rodger L. Foltz

The Determination of Morphine in Urine and Oral Fluid Following Ingestion of Poppy Seeds
Timothy P. Rohrig and Christine Moore

Occupational Cocaine Exposure of Crime Laboratory Personnel Preparing Training Aids for a Military Working Dog Program
Jay M. Gehlhausen, Kevin L. Klette, Peter R. Stout, and JoAnn Given

LC–MS Analysis of 2-Oxo-3-Hydroxy LSD from Urine Using a Speedisk Positive Pressure Processor with Cerex PolyChrom CLIN II Columns
Carl K. Horn, Kevin L. Klette, and Peter R. Stout

Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronides in Urine by Liquid Chromatography–Mass Spectrometry
Robert Kronstrand, Tor Seldén, and Martin Josefsson

Performance Characteristics of Selected Immunoassays for Preliminary Test of 3,4-Methylenedioxymethamphetamine, Methamphetamine, and Related Drugs in Urine Specimens
Jui Hsu, Chiareiy Liu, C.P. Hsu, Wen-Ing Tsay, Jih-Heng Li, Dong-Liang Lin, and Ray H. Liu

Metabolic Profile of Amphetamine and Methamphetamine Following Administration of the Drug Famprofazine
Brandy Greenhill, Sandra Valtier, and John T. Cody

Amphetamine Enantiomer Excretion Profile Following Administration of Adderall
John T. Cody, Sandra Valtier, and Stephen L. Nelson

Postmortem Indentification and Quantitation of 2,5-Dimethoxy-4-n-propylthiophenethylamine Using GC–MSD and GC–NPD
Byron Curtis, Philip Kemp, Linda Harty, Chai Choi, and Dix Christensen

Fentanyl Misuse and Abuse: A Summary of 23 Postmortem Cases
James J. Kuhlman, Jr., Rebecca McCaulley, Tara J. Valouch, and George S. Behonick

Development of a Rapid and Sensitive Method for the Quantitation of Benzodiazepines in Calliphora vicina Larvae and Puparia by LC–MS–MS
M. Wood, M. Laloup, K. Pien, N. Samyn, M. Morris, R.A.A. Maes, E.A. de Bruijn, V. Maes, and G. De Boeck

TECHNICAL NOTE: Analysis of Fentanyl and Norfentanyl in Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry Using Electrospray Ionization
J. Day, M. Slawson, R.A. Lugo, and D. Wilkins

TECHNICAL NOTE: Stability of Ethanol in Postmortem Blood and Vitreous Humor in Long-Term Refrigerated Storage
Theresa Olsen and W. Lee Hearn

TECHNICAL NOTE: Caffeine Content of Specialty Coffees
Rachel R. McCusker, Bruce A. Goldberger, and Edward J. Cone

CASE REPORT: Fatal Cold Medication Intoxication in an Infant
Diane M. Boland, Joseph Rein, Emma O. Lew, and W. Lee Hearn

CASE REPORT: Buprenorphine in Drug-Facilitated Sexual Abuse: A Fatal Case Involving a 14-Year-Old Boy
Pascal Kintz, Marion Villain, Antoine Tracqui, Vincent Cirimele, and Bertrand Ludes

LETTER TO THE EDITOR: Evaluation of a Solid-Phase Extraction Method for Codeine and Morphine in Urine Using Cerex Polychrom™ Clin II Columns and the Speedisk™ 48 Pressure Processor at a High-Throughput Forensic Drug-Testing Laboratory
Melissa M. Churley, Timothy P. Lyons, Paul V. Robrandt, and Mark R. Bruins

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October SOFT issue 2002
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Correlation Between Pharmacological Effects and Plasma Cocaine Concentrations after Smoked Administration,
Amanda J. Jenkins, Robert M. Keenan, Jack E. Henningfield, and Edward J. Cone

Urinary Elimination of Cocaine Metabolites in Chronic Cocaine Users During Cessation,
Kenzie L. Preston, David H. Epstein, Edward J. Cone, Abraham T. Wtsadik, Marilyn A. Huestis, and Eric T. Moolchan

Evaluation of a Solid-Phase Extraction Method for Benzoylecgonine Urine Analysis in a High-Throughput Forensic Urine Drug-Testing Laboratory,
Peter R. Stout, Jay M. Gehlhausen, Carl K. Horn, and Kevin L. Klette

Storage Stability of Simulator Ethanol Solutions for Vapor-Alcohol Control Tests in Breath-Alcohol Analysis,
Kurt M. Dubowski, Emmett E. Goodson, and McBeth Sample, Jr.

Improved Screen and Confirmation Test of 7-Aminoflunitrazepam in Urine Specimens for Monitoring Flunitrazepam (Rohypnol) Exposure,
Perng-Haur Wang, Chiareiy Liu, Wen-Ing Tsay, Jih-Heng Li, Ray H. Liu, Tai-Guang Wu, Wen-Jing Cheng, Dong-Liang Lin, Tsun-Ying Huang, and Cheng-Hsing Chen

The Defined HHS/DOT Substituted Urine Criteria Validated Through a Controlled Hydration Study,
Kenneth Edgell, Yale H. Caplan, Leon R. Glass, and Janine Denis Cook

Evaluation of Freezing Point Depression Osmolality for Classifying Random Urine Specimens Defined as Substituted Under HHS/DOT Criteria,
Janine Denis Cook, Mark W. Hannon, Sr., Tamdan Vo, and Yale H. Caplan

Quantitative Analysis of Selegiline and Three Metabolites (N-Desmethylselegiline, Methamphetamine, and Amphetamine) in Human Plasma by High-Performance Liquid Chromatography–Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry,
Matthew H. Slawson, James L. Taccogno, Rodger L. Foltz, and David E. Moody

Pharmacogenomics as Molecular Autopsy for Postmortem Forensic Toxicology: Genotyping Cytochrome P450 2D6 for Oxycodone Cases,
Paul J. Jannetto, Steven H. Wong, Susan B. Gock, Elvan Laleli-Sahin, B. Charles Schur, and Jeffrey M. Jentzen

Oxycontin®: The Concept of a “Ghost Pill” and the Postmortem Tissue Distribution of Oxycodone in 36 Cases,
Daniel T. Anderson, Kristina L. Fritz, and Joseph J. Muto

Effects of Oxidizing Adulterants on Detection of 11-Nor-Δ9-THC-Carboxylic Acid in Urine,
Buddha D. Paul and Aaron Jacobs

Performance Evaluation of Three On-Site Adulterant Detection Devices for Urine Specimens,
Michelle R. Peace and Lisa D. Tarnai

Deposition of 7-Aminoclonazepam and Clonazepam in Hair Following a Single Dose of Klonopin™,
Adam Negrusz, Andrew M. Bowen, Christine M. Moore, Sheila M. Dowd, Mary Jane Strong, and Philip G. Janicak

Segmental Ion Spray LC–MS–MS Analysis of Benzodiazepines in Hair of Psychiatric Patients,
Robert Kronstrand, Ingrid Nyström, Martin Josefsson, and Sheilagh Hodgins

An Evaluation of Two Wash Procedures for the Differentiation of External Contamination versus Ingestion in the Analysis of Human Hair Samples for Cocaine,
Michael I. Schaffer, Wen-Ling Wang, and John Irving

Detection of Cocaine Analytes and Opiates in Nails Postmortem Cases,
David A. Engelhart and Amanda J. Jenkins

A Field Evaluation of Five On-Site Drug-Testing Devices,
Dennis J. Crouch, Rebekah K. Hersch, Royer F. Cook, James F. Frank, and J. Michael Walsh

An Evaluation of the OnTrak Testcup®-er On-Site Urine Drug Testing Device for Drugs Commonly Encountered in Emergency Departments,
Michelle R. Peace, Justin L. Poklis, Lisa D. Tarnai, and Alphonse Poklis

Validation of a Microtiter Plate ELISA for Screening of Postmortem Blood for Opiates and Benzodiazepines,
Philip Kemp, Gary Sneed, Tom Kupiec, and Vina Spiehler

Choice of an ELISA Assay for Screening Postmortem Blood for Amphetamine and/or Methamphetamine,
Tom Kupiec, Lacinda DeCicco, Vina Spiehler, Gary Sneed, and Philip Kemp

Comparison of EMIT®II, CEDIA®, and DPC® RIA Assays for the Detection of Lysergic Acid Diethylamide in Forensic Urine Samples,
Russell F. Wiegand, Kevin L. Klette, Peter R. Stout, and Jay M. Gehlhausen

TECHNICAL NOTE: Simultaneous Quantitation of Opioids in Blood by GC–EI-MS Analysis Following Deproteination, Detautomerization of Keto Analytes, Solid-Phase Extraction, and Trimethylsilyl Derivatization,
Jeri D. Ropero-Miller, Matthew K. Lambing, and Ruth E. Winecker

CASE REPORT: Blood Investigation in a Fatality Involving the Veterinary Drug T-61,
P. Kintz, V. Cirimele, and B. Ludes

CASE REPORT: Death by Paint Thinner,
Ines Collison and Wayne Moorehead

LETTER TO THE EDITOR: Differentiation of the 2,3-Methylenedioxy Regioisomer of 3,4-MDMA (Ecstasy) by Gas Chromatography–Mass Spectrometry
John T. Cody and Sandra Valtier

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October 2001 Special Issue: Society of Forensic Toxicologists, Inc.
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Effect of Four Laboratory Decontamination Procedures on the Quantitative Determination of Cocaine and Metabolites in Hair by HPLC–MS
Ryan B. Paulsen, Diana G. Wilkins, Matthew H. Slawson, Kimberly Shaw, and Douglas E. Rollins

A Validated Liquid Chromatography–Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry Method for Quantitation of Cocaine and Benzoylecgonine in Human Plasma
Shen-Nan Lin, David E. Moody, George E. Bigelow, and Rodger L. Foltz

Urinary Excretion Profiles for Total Morphine, Free Morphine, and 6-Acetylmorphine Following Smoked and Intravenous Heroin
Michael L. Smith, Eric T. Shimomura, Jacquelyn Summers, Buddha D. Paul, Amanda J. Jenkins, W. David Darwin, and Edward J. Cone

Detection of Opiate Use in a Methadone Maintenance Treatment Population with the CEDIA® 6-Acetylmorphine and CEDIA DAU Opiate Assays
Alan C. Spanbauer, Scott Casseday, David Davoudzadeh, Kenzie L. Preston, and Marilyn A. Huestis

Gas Chromatography–Mass Spectrometry Confirmation of Cozart RapiScan Saliva Methadone and Opiate Tests
Lesley Moore, John Wicks, Vina Spiehler, and Richard Holgate

Cathinone (Khat) and Methcathinone (CAT) in Urine Specimens: A Gas Chromatographic–Mass Spectrometric Detection Procedure
Buddha D. Paul and Kenneth A. Cole

Simultaneous Determination of D9-Tetrahydrocannabinol and 11-nor-9-Carboxy-D9-Tetrahydrocannabinol in Human Plasma by Solid-Phase Extaction and Gas Chromatography–Negative Ion Chemical Ionization-Mass Spectrometry
Wei Huang, David E. Moody, David M. Andrenyak, Elizabeth K. Smith, Rodger L. Foltz, Marilyn A. Huestis, and John F. Newton

Temporal Indication of Marijuana Use Can Be Estimated from Plasma and Urine Concentrations of D9-Tetrahydrocannabinol, 11-Hydroxy-D9-Tetrahydrocannabinol, and 11-nor-Æ9-Tetrahydrocannabinol-9-Carboxylic Acid
Joseph E. Manno, Barbara R. Manno, Philip M. Kemp, Dempsey D. Alford, Imad K. Abukhalaf, Mary E. McWilliams, Frances N. Hagaman, and Mary Jo Fitzgerald

Solid-Phase Extraction and GC–MS Analysis of THC-COOH Method Optimized for a High-Throughput Forensic Drug-Testing Laboratory
Peter R. Stout, Carl K. Horn, and Kevin L Klette

The Determination of 11-nor-D9-Tetrahydrocannabinol-9-Carboxylic Acid (THC-COOH) in Hair using Negative Ion Gas Chromatography–Mass Spectrometry and High-Volume Injection
Christine Moore, Frank Guzaldo, and Thomas Donahue

A Comparison of Roche Kinetic Interaction of Microparticles in Solution (KIMS®) Assay for Cannabinoids and GC–MS Analysis for 11-nor-9-Carboxy-D9-Tetrahydrocannabinol
Timothy P. Lyons, Catherine K. Okano, Judith A. Kuhnle, Mark R. Bruins, William D. Darwin, Eric T. Moolchan, and Marilyn A. Huestis

D9-Tetrahydrocannabivarin as a Marker for the Ingestion of Marijuana versus Marinol®: Results of a Clinical Study
Mahmoud A. ElSohly, Harriet deWit, Stephen R. Wachtel, and Timothy P. Murphy

Analysis of Morphine and Codeine in Samples Adulterated with Stealth™
John T. Cody, Sandra Valtier, and James Kuhlman

Application of a Convenient Extraction Procedure for the Analysis of Gamma-Hydroxybutyric Acid in Fatalities Involving Gamma-Hydroxybutyric Acid, Gamma-Butyrolactone, and 1,4-Butanediol
W.C. Duer, K.L. Byers, and J.V. Martin

Urine Concentrations of Ketamine and Norketamine Following Illegal Consumption
Karla A. Moore, Jason Sklerov, Barry Levine, and Aaron J. Jacobs

Hydrolysis of Conjugated Metabolites of Buprenorphine. I. The Quantitative Enzymatic Hydrolysis of Buprenorphine-3-b-D-Glucuronide in Human Urine
Shixia Feng, Mahmoud A. ElSohly, and David T. Duckworth

Incorporation of Selegiline Metabolites into Hair after Oral Selegiline Intake
Robert Kronstrand, Maria Choi Andersson, Johan Ahlner, and Göran Larson

Development of a Generic Method to the Solid-Phase Extraction of Acidic Compounds from Complex Matrices
Diane M. Boland, M