| Development of a Homogeneous Immunoassay for the Detection of Zolpidem in Urine |
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Sleep disorders are common conditions that affect about 40 million people in the U.S every year, the most common of which is insomnia, which is characterized by difficulty falling or staying asleep. Zolpidem (Ambien®) is a non-benzodiazepine prescription |
| Zaleplon (Sonata®) Analysis in Postmortem Specimens by Gas Chromatography–Electron Capture Detection |
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Zaleplon (Sonata) is a sedative hypnotic prescription medication used for the short-term treatment of insomnia. |
| Determination of Specific Absorbance (A¦) for Zaleplon (Sonata®) by Spectrophotometry |
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Specific absorbance (A¦) is the maximum absorbance of a 1% solution over a 1-cm path length as measured by a spectrophotometer. If a reliable A¦ determination is available for a drug, it provides an extremely useful tool for the quantitative verification |
| Implications of Plasma Δ9-Tetrahydrocannabinol, 11-Hydroxy-THC, and 11-nor-9-Carboxy-THC Concentrations in Chronic Cannabis Smokers |
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Δ9-Tetrahydrocannabinol (THC) is commonly found in toxicological specimens from driving under the influence and accident investigations. Plasma cannabinoid concentrations were determined in 18 long-term heavy cannabis smokers residing on an in-patient res |
| Solid-Phase Extraction and Analysis of THC and Carboxy-THC from Whole Blood Using a Novel Fluorinated Solid-Phase Extraction Sorbent and Fast LC–Tandem MS |
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In this study, solid-phase extraction (SPE) is described using a novel fluorinated [heptadecafluorotetrahydrodecyl (C10H4F17)] phase to isolate THC and its primary metabolite carboxy-THC from whole blood samples. |
| Automated SPE-LC–MS–MS Analysis of 11-nor-Δ9-THC-9-Carboxylic Acid in Human Urine Specimens: Application to a High-Throughput Urine Analysis Lab |
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An automated solid-phase extraction coupled with liquid chromatography and tandem mass spectrometry (SPE-LC–MS–MS) method for the analysis of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in human urine specimens was developed. |
| Sensitive Method For Detection Of Cocaine And Associated Analytes By Liquid Chromatography–Tandem Mass Spectrometry In Urine |
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Cocaine (COC) is a potent CNS stimulant that is metabolized to benzoylecgonine (BE) and further metabolized to minor metabolites such as m-hydroxybenzoylecgonine (m-HOBE). COC is also metabolized to norcocaine (NC). Cocaethylene (CE) is formed when cocain |
| Urinary MDMA, MDA, HMMA, and HMA Excretion Following Controlled MDMA Administration to Humans |
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The aim of this paper is to describe the pattern and timeframe of excretion of MDMA and its metabolites in urine. Placebo, 1.0 mg/kg, and 1.6 mg/kg oral MDMA doses were administered double-blind to healthy adult MDMA users on a monitored research unit. |
| Comparison of Oxycodone in Vitreous Humor and Blood Using EMIT® Screening and Gas Chromatographic–Mass Spectrometric Quantitation |
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Vitreous humor may serve as a useful alternative specimen for oxycodone analysis in death investigations where blood samples are not available or are of poor quality or limited quantity. The purpose of this study was to investigate the relationship betwee |
| Oxycodone-Related Fatalities in the West of Scotland |
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The intent of this study was to review fatalities involving oxycodone in the west of Scotland using a liquid chromatography–electrospray ionization-tandem mass spectrometry method developed for the determination of oxycodone and N- and O-demethylated meta |
| Potential Biomarkers of Smoked Fentanyl Utilizing Pyrolysis Gas Chromatography–Mass Spectrometry |
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Fentanyl is a potent opioid analgesic that is increasingly becoming a choice drug of abuse. Fentanyl transdermal patches (FTPs) are easily obtained and consumed by smoking the reservoir gel and/or the whole patch. This allows for an increased bioavailabil |
| Determination of Naloxone and Nornaloxone (Noroxymorphone) by High-Performance Liquid Chromatography–Electrospray Ionization-Tandem Mass Spectrometry |
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A highly sensitive method was developed to measure naloxone and its metabolite nornaloxone in human plasma, urine, and human liver microsomes (HLM). |
| A Comparison of the Validity of Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Urine Samples for Morphine |
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On November 25, 2008, the U.S. Department of Health and Human Services posted a final notice in the Federal Register authorizing the use of liquid chromatography–tandem mass spectrometry (LC–MS–MS) and other technologies in federally regulated workplace d |
| Letter to the Editor: Ethylene Glycol Poisoning and Lactate Concentrations |
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To the Editor: |
| Letter to the Editor: Deuterated Therapeutics: Forensic Toxicology Consequences |
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To the Editor: |
| Case Report: Lethal Poisoning with Ethiofencarb and Ethanol |
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Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethio |
| Determination of Trace Cantharidin in Plasma and Pharmacokinetic Study in Beagle Dogs Using Gas Chromatography–Mass Spectrometry |
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The blister beetle is traditional Chinese medicine that was first discovered and used as anticancer drug in China, and cantharidin proved to be its principal active ingredient. Cantharidin-based pharmaceutical preparations are now widely used in clinics i |
| Unstable Propoxyphene Metabolite Excreted in Human Urine is Detected by Liquid Chromatography–Tandem Mass Spectrometry |
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A “dilute and shoot” method for measuring norpropoxyphene in human urine using liquid chromatography–tandem mass spectrometry distinguishes two different metabolites of propoxyphene, norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 30 |
| Determination of Digoxin and Digitoxin in Whole Blood |
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A liquid chromatography–tandem mass spectrometry (LC–MS–MS) method has been developed and validated for the determination of digoxin and digitoxin in whole blood samples in autopsy cases. Samples were prepared by liquid–liquid extraction (LLE) with ethyl |
| Methylenedioxymethamphetamine-Related Deaths in Taiwan: 2001–2008 |
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Methylenedioxymethamphetamine (MDMA) has been one of most popular drugs in the “club” scene in Taiwan. This epidemic was studied through the examination of toxicological data obtained from the 59 fatalities tested positive for MDMA during the period of Ja |