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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 32, Number 1, January/February,
pp.1
EDITORIAL: Analysis of Biological Samples
for Chemical Warfare Agents
John R. Barr
Centers for Disease Control and Prevention, Atlanta, Georgia
The analysis of biological samples to assess exposure
to chemical warfare agents (CWA) is critical for responding to
a terrorist attack, accidental release, or military use of these
agents. By measuring the intact agent, its metabolite, or a DNA
or protein adduct in a clinical sample, scientists can identify
the agent that was used and the individuals who were exposed.
Quantification of biomarkers of exposure to CWA in clinical samples
can determine the amount of agent that entered the body by all
exposure routes and the biologically effective dose of the agent
that is present to cause toxic effects at the target site. Biological
monitoring does not require complex modeling to estimate internal
dose and will often give the best estimate of individual exposure.
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