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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 32, Number 3, April,
pp.260-265
CASE REPORT:
Determination of Fentanyl in Sweat and Hair of a Patient using
Transdermal Patches
Serge Schneider1, Zahra Ait-m-bark1, Claude Schummer1, Patrick
Lemmer1, Michel Yegles1, Brice Appenzeller2, and Robert Wennig1
1Laboratoire National de Santé, Division de Toxicologie,
Université du Luxembourg, 162a, avenue de la Faïencerie,
L-1511 Luxembourg and
2CRP-Santé, Laboratoire National de
Santé, L-1511 Luxembourg
Fentanyl is a synthetic opioid used to treat intense
chronic pain. In this study, the authors report detection and
quantification of fentanyl in sweat and hair of a patient receiving
fentanyl (25 µg/h) via a transdermal therapeutic system
(TTS) for 22 days. Sweat was collected using sweat patches every
night on days 13–21 of the therapy, and hair was collected
12 weeks after the end of the treatment. Detection and quantification
was performed with liquid chromatography–tandem mass spectrometry
using electron spray ionization in selected reaction monitoring
mode. Alfentanyl was used as internal standard for quantification
in hair and in sweat. Sodium ions have been used as endogenous
internal reference for determination of volume of sweat excreted
on each patch. Results show presence of fentanyl in both matrices.
Fentanyl concentrations in sweat varied from 0.17 to 1.02 ng/µL,
and time-resolved segmented hair analysis showed a maximum fentanyl
concentration of 0.48 ng/mg of hair during the period of the
therapy.
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