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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 32, Number 3, April,
pp.232-240
Analysis of
Confiscated Black Market Drugs Using Chromatographic and Mass Spectrometric
Approaches
Mario Thevis, Yvonne Schrader, Andreas Thomas,
Gerd Sigmund, Hans Geyer, and Wilhelm Schänzer
Center for Preventive Doping Research—Institute of Biochemistry,
German Sport University Cologne, Carl-Diem Weg 6, 50933 Cologne,
Germany
In the context of house searches in Germany, numerous
drugs were confiscated and subjected to chemical analysis, including
anabolic agents such as various anabolic-androgenic steroids
(stanozolol, testosterone derivatives, trenbolone esters, etc.)
and clenbuterol, as well as agents with anti-estrogenic activity
(tamoxifen, clomiphene), drugs stimulating virility (sildenafil,
tadalafil), and unlabeled plastic bags. Liquid chromatography–tandem
mass spectrometry, gas chromatography–mass spectrometry
with nitrogen-phosphorus specific detection, gel electrophoresis,
and immunological tests were employed to test for the effective
content of 70 products. In 18 cases (25.7%), the declared ingredients
differed from the actual content, in particular concerning anabolic-androgenic
steroids. Nandrolone and trenbolone esters, for instance, were
frequently substituted or complemented by various testosterone
derivatives, and several testosterone depot formulations originally
composed of four different esters were found to contain fewer
or wrong components. Except for those drugs supposedly originating
from so-called underground labs, fake packings were hardly or
not distinguishable from original boxes by visual inspection.
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