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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 31, Number 8, October,
pp.534-536
CASE REPORT: A Fatality from Sevoflurane
Abuse
Barry Levine[1,2], Dawn Cox[2],
Rebecca A. Jufer-Phipps[1], Ling Li[1], Aaron Jacobs[3], and
David Fowler[1]
[1]Office of the Chief Medical Examiner, State of Maryland, 111
Penn St., Baltimore, Maryland 21201;
[2]Office of the Armed Forces
Medical Examiner, 1413 Research Blvd., Building 102, Rockville,
Maryland 20850; and
[3]U.S. Army, 23610 Silversmith, San Antonio,
Texas 78258
A case is presented of a 47-year-old man who died
as a result of sevoflurane abuse. Sevoflurane was identified
and confirmed by headspace gas chromatography–mass spectrometry.
The heart blood sevoflurane concentration was 16 mg/L, and the
peripheral blood sevoflurane concentration was 8.0 mg/L. No drugs
or other volatile substances were found in the heart blood. The
medical examiner ruled that the cause of death was cardiac arrhythmia
due to sevoflurane toxicity. Cardiomegaly was listed on Part
II of the death certificate. The manner of death was undetermined.
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