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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 31, Number 4, May 2007,
pp. 233-236
CASE REPORT: Postmortem Memantine Concentrations
Nichole Bynum, Justin Poklis, Diana Garside,
and Ruth Winecker
Office of the Chief Medical Examiner, Chapel Hill, North Carolina
Postmortem fluid and tissue concentrations of memantine
(Namenda™), a drug recently approved for the treatment of
Alzheimer’s Disease by the FDA, are reported in a suspicious
death. In addition, memantine concentrations considered to be
incidental findings in three other cases are included to aid in
the interpretation in future toxicological investigations. Memantine
was extracted from biological samples by a standard liquid–liquid
basic drug method followed by analysis utilizing a gas chromatograph–mass
spectrometer operated in SIM mode. Blood concentrations ranged
from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.
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