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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Number 8, October 2006,
pp.516-518
Determination of Propoxyphene in Oral Fluid
Sumandeep Rana, Christine Moore, Michael Vincent, Cynthia Coulter, Alpana
Agrawal, and James Soares
Immunalysis Corporation, 829 Towne Center Drive, Pomona, California 91767
The determination of propoxyphene in oral fluid using solid-phase
extraction and gas chromatography–mass spectrometry is described for the
first time. The method employs collection of oral fluid with the Quantisal™
device, immunoassay screening of the specimen, confirmation of the positive
screened samples after extraction using cation exchange/hydrophobic solid-phase
extraction columns, optimized derivative formation, and gas chromatography–mass
spectrometry in electron impact mode. Validated parameters including selectivity,
linearity, accuracy, intra- and interday precision, extraction efficiency, and
limit of quantitation were all within acceptable limits. The method was applied
to authentic specimens taken from an individual prescribed propoxyphene following
surgery.
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