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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Number 9, November/December 2006,
pp.703-704
LETTER TO THE EDITOR: Detection of Ethylglucuronide in
Urine following the Application of Germ-X
Timothy P. Rohrig[1], Connie Huber[1], Lana Goodson[1],
and Wayne Ross[2]
[1]Regional Forensic Science Center, Wichita, Kansas
[2]Redwood Toxicology Laboratory, Santa Rosa, California
Ethylglucuronide (EtG) is a non-volatile, water-soluble direct
metabolite of ethanol, a biological state marker of recent alcohol consumption,
that is becoming a routine assay in many laboratories (1). It can be detected
for an extended time period (up to 5 days) after alcohol is completely eliminated
from the body and has found wide acceptance in the detection of relapse in recovering
alcoholics, monitoring of medical professionals, and detection in postmortem
specimens (2,3). There is a great deal of literature on the methodology of detection
of EtG in urine, serum, plasma, and hair (4,5), but an accepted “cut-off”
concentration for urine analysis has not been widely adopted. Although several
publications list the limit of quantitation between 0.05 and 0.5 mg/L of urine,
cut-offs in commercial laboratories in the U.S. range from 0.10 to 1.0 mg/L.
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