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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Number 9, November/December 2006,
pp.670-678
Quantification of Dichloroiodomethane and Bromochloroiodomethane
in Human Blood by Solid-Phase Microextraction Coupled with Gas Chromatography–High-Resolution
Mass Spectrometry
Lalith K. Silva[1], Michael A. Bonin[1], Bruce McKague[2],
and Benjamin C. Blount[1]
[1]Division of Laboratory Sciences, National Center for Environmental Health,
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 and
[2]CanSyn Chemical Corporation, 200 College Street, Toronto, Ontario M5S 3E5,
Canada
Iodine-containing trihalomethanes (iodo-THMs) are formed as disinfection
byproducts when iodide-containing water is disinfected using chloramination
process. Subsequent water use may lead to human exposure to iodo-THMs. Because
of health concerns surrounding exposure to iodo-THMs, a rapid, reliable, and
high-throughput analytical method was developed to quantify trace levels of
two iodo-THMs: dichloroiodomethane (IDCM) and bromochloroiodomethane (IBCM)
in human blood. These analytes from the headspace above blood samples were extracted
using solid-phase microextraction. Analytes were then desorbed and separated
by capillary gas chromatography and analyzed by high-resolution mass spectrometry
with multiple ion monitoring. This method utilizes stable isotope dilution to
quantify parts-per-trillion levels of all analytes, with excellent precision
of < 9% coefficient of variation. At three spiked levels, method accuracy
of IDCM and IBCM ranged between 6 and 20% difference when comparing spiked and
measured amounts. The method limit of detection was 2 ng/L for both IDCM and
IBCM. This selective, sensitive, and rapid method will help to assess human
exposure to iodo-THMs and to study potential associations between exposure and
adverse health outcomes.
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