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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Issue 5, June 2006,
pp.342-345
CASE REPORT: Psilocin Identified in a DUID Investigation
Nicholas B. Tiscione and Mattheu I. Miller
Florida Department of Law Enforcement, Orlando Regional Operations Center, 500
West Robinson Street, Orlando, Florida 32801
Psilocin was identified in a urine specimen collected during a
routine driving under the influence of drugs investigation, the first for this
laboratory. The subject did not exhibit any response to an automobile crash,
indicating the he may have been unaware of the severity of the situation or
his immediate surroundings. The urine specimen gave a positive result on a fluorescence
polarization immunoassay amphetamine/methamphetamine assay, and psilocin was
determined to have 1.3% cross-reactivity at 50 mg/L. Psilocin was confirmed
by gas chromatography–mass spectrometry following an extraction for acidic,
neutral, and basic drugs. Hydrolysis and derivatization techniques were not
employed. The urine concentration of psilocin decreased rapidly, although the
specimen was maintained at 4°C.
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