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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Issue 5, June 2006,
pp.335-341
CASE REPORT: Analysis of 13 Fentanils, Including Sufentanil
and Carfentanil, in Human Urine by Liquid Chromatography–Atmospheric-Pressure
Ionization-Tandem Mass Spectrometry
Lanqing Wang and John T. Bernert
Emergency Response and Air Toxicants Branch, Division of Laboratory Science,
National Center for Environmental Health, Centers for Disease Control and Prevention,
4770 Buford Highway, NE, Mailstop F-47, Atlanta, Georgia 30341
A sensitive, semiautomated method for the analysis of several
fentanils and fentanil metabolites in human urine is described. This method
uses solid-phase extraction of urine samples followed by liquid chromatography–atmospheric
pressure ionization-tandem mass spectrometry. Isotopically labeled internal
standards were included for 6 of the 13 analytes in this study. Estimated detection
limits ranged from 3 to 27 pg/mL, and good accuracy and long-term precision
were observed in most cases. This method should be useful for the rapid and
sensitive screening of human urine samples for a number of fentanils and their
metabolites as indicators of exposure.
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