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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Issue 5, June 2006,
pp.331-334
CASE RPORT: Tizanidine Distribution in a Postmortem Case
Jason H. Sklerov[1], Dawn E. Cox[1], Karla A. Moore[2],
Barry Levine[1,2], and David Fowler[2]
[1]Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner,
1413 Research Blvd., Bldg. 102, Rockville, Maryland 20850 and
[2]Office of the Chief Medical Examiner, 111 Penn St., Baltimore, Maryland 21201
The case of a 57-year-old white female who was found deceased
at home by her husband is presented. A suicide note was found at the scene.
No remarkable findings were observed at autopsy. Comprehensive toxicological
analysis of the heart blood identified ethanol (0.16 g/dL), diazepam (1.1 mg/L),
and tizanidine (2.3 mg/L). Blood concentrations of tizanidine following therapeutic
use do not exceed 0.025 mg/L. The medical examiner ruled that the cause of death
was combined ethanol and multiple drug intoxication, and the manner of death
was suicide.
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