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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Issue 6, July/August 2006,
pp.406-407
LETTER TO THE EDITOR: A Demand for Clarity Regarding a
Case Report on the Ingestion of 5-Methoxy-N, N-Dimethyltryptamine (5-MeO-DMT)
in an Ayahuasca Preparation
J.C. Callaway[1], Charles S. Grob[2], Dennis J. McKenna[3], David E.
Nichols[4], Alexander Shulgin[5], and Kenneth W. Tupper[6]
[1]Associate Professor of Pharmaceutical Chemistry, University of Kuopio, Finland;
[2]Professor of Psychiatry and Pediatrics, UCLA School of Medicine, Director
of the Division of Child Adolescent Psychiatry, Harbor-UCLA Medical Center;
[3]Centre for Spirituality & Healing, University of Minnesota, Director
of Ethnopharmacology, Heffter Research Institute;
[4]Medicinal Chemistry and Molecular Pharmacology, Purdue University, Professor
of Medicinal Chemistry and Molecular Pharmacology;
[5]Pharmacologist, Chemist; and
[6]University of British Columbia—Educational Studies #120-6201, Cecil
Green Park Rd., Vancouver, BC,V6T 1Z1, Canada
The case report “A Fatal Intoxication Following the Ingestion
of 5-Methoxy-N,N-Dimethyltryptamine in an Ayahuasca Preparation” by Sklerov
et al. is misleading as to the nature and toxicity of ayahuasca. The authors
of the article state that: “the decedent ingested a preparation from a
South American tree bark ‘ooasca’ (sic) and approximately 4 h later
ingested tryptamines”. However, elsewhere in the article they assert that
this is a case of “administration of an ayahuasca-like preparation containing
5-MeO-DMT”and further, that “this is the only reported case of death
following ingestion of hallucinogenic tryptamines contained in an ayahuasca
preparation”. The article’s title also purports that this is a case
of “5-Methoxy-N,N-Dimethyltryptamine in an Ayahuasca Preparation”
(italics added).
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