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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 30, Issue 6, July/August 2006,
pp.403-405
LETTER TO THE EDITOR: Postmortem Distribution of Sildenafil
in Histological Material
Mariano Cingolani
Institute of Legal Medicine, University of Macerata, Via Don Minzoni n. 9, I-62100
Macerata, Italy
We would like to comment on the Technical Note “Postmortem
Distribution of Sildenafil in Histological Material” of Pagani et al..
The authors describe a method to detect and quantify sildenafil in biological
fluids and tissues as well as in formalin stabilized fluids and tissues. Recently,
we received a forensic case involving a drug addict, and together with the biological
samples, a white powder was also submitted for analysis. Using the method as
described, the results indicated the presence of sildenafil. However, because
there was absolutely no suspicion about the use of sildenafil in this case,
we repeated the analysis using our gas chromatography–mass spectrometry
(GC–MS) method in scan mode and with the NIST98 GC–MS library for
identification. The results of this analysis indicated the presence of citric
acid 4-TMS, which was more plausible because citric acid is often used to dissolve
heroine prior to injection.
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