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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26, Number 4, May/June,
pp. 243-248
TECHNICAL NOTE: Postmortem Toxicology of Carbamazepine
Malgorzata Klys[1], Beata Bystrowska[2], and Beata
Bujak-Gizycka[1]
[1]Collegium Medicum Jagiellonian University, Institute of Forensic Medicine,
Department
of Toxicology, 16 Grzegórzecka Street,
31-531 Kraków, Poland
and [2]Collegium Medicum Jagiellonian University,
Department of Toxicology, Faculty of Pharmacy,
9 Medyczna Street, 30-688 Kraków, Poland
The study focuses on a series of 16 fatal cases in which carbamazepine
and its two major metabolites (10,11-epoxide and 10,11-dihydroxycarbamazepine)
were detected in body fluids and tissues collected at autopsy. The drug may
be implicated in a number of deaths; however, most of these are multiple-drug
intoxications with a particular contribution of ethanol. The investigations
concerning toxicological findings are a source of toxicological postmortem
data and show the differences in metabolism rate as depending on the concentration
level of carbamazepine and xenobiotics found in the autopsy specimen during
the postmortem investigation of a body. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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