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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26, Number 4, May/June,
pp. 221-225
Acute Nitrobenzene Poisoning with Severe Associated Methemoglobinemia:
Identification in Whole Blood by GC–FID and GC–MS
M.A. Martínez[1], S. Ballesteros[2], E. Almarza[1],
C. Sánchez
de la Torre[1], and S. Búa[3]
[1]Chemistry Department, National Institute of Toxicology, Ministry of Justice,
C/Luis Cabrera 9, 28002 Madrid, Spain;
[2]Spanish Poison Control Center, National
Institute of Toxicology, Madrid, Spain; and
[3]Intensive
Care Unit, Hospital de Móstoles, C/Río Júcar, s/n, 28935
Móstoles,
Madrid, Spain
A rare fatal case of self-poisoning with nitrobenzene following
oral ingestion is reported. On presentation to the hospital, severe methemoglobinemia
(70%) was observed in an 82-year- old male who had ingested 250 mL of an unknown
substance in the previous 24 h. Methylene blue and exchange transfusion were
the therapeutic methods applied in the treatment of the methemoglobinemia.
Forty-eight hours after ingestion, a blood sample was collected in ICU and
sent to our laboratory. We detected that the blood contained 3.2 µg/mL
of nitrobenzene. The determination of nitrobenzene was performed using the
combination of GC–FID for screening analysis and quantitation and GC–MS
for confirmation of the obtained results. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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