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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 27, Number 1, January/February
2003,
pp. 20-23
Interindividual Dose/Concentration Relationship for Methadone in Hair
Sue Paterson and Rosa Cordero
Toxicology Unit, Imperial College Faculty of Medicine, St. Dunstan’s
Road, London, England W6 8RP
Mike McPhillips and Suzannah Carman
Substance Misuse Service, Brent, Kensington, Chelsea and Westminster Mental
Health Trust, 184 Hammersmith Road, London, England W6 7DJ
Hair samples were collected from 60 patients receiving long-term
methadone maintenance: 50 were taking the drug orally and 10 were receiving
the drug by intravenous injection. The amount of methadone present in the hair
samples was measured using methanolic extraction, derivatization of the extracts
with MTBSTFA, followed by electron impact gas chromatography–mass spectrometry
operating in selected ion monitoring mode. The limit of quantitation for the
assay was 0.4 ng/mg hair. The dose/concentration relationship for methadone
in hair was investigated. No interindividual correlation between prescribed
dose and concentration of methadone in hair was observed.
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