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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 27, Number 3, April 2003,
pp. 135-141
Quantitative Analysis of Desmethylselegiline, Methamphetamine,
and Amphetamine in Hair and Plasma from Parkinson Patients on Long-Term Selegiline
Medication
Robert Kronstrand[1], Johan Ahlner[1], Nil Dizdar[2],
and Göran Larson[3]
[1]National Board of Forensic Medicine, Department of Forensic Chemistry, Linköping
University Hospital, SE-581 85 Linköping, Sweden;
[2]Linköping University
Hospital, Department of Neurology, SE-581 85 Linköping, Sweden; and
[3]Sahlgrenska
University Hospital, Department of Clinical Chemistry and Transfusion Medicine,
SE-413 45 Göteborg, Sweden
Hair and plasma from patients
on long-term selegiline medication were analyzed to evaluate the relationships
between plasma and
hair melanin concentrations and the incorporation of the selegiline metabolites
methamphetamine and amphetamine in hair, and to evaluate hair analyses for
determining compliance in medication. Analyses were performed on both the
whole hairs, as well as pigmented and non-pigmented hairs from gray-haired
patients. Melanin was quantitated by spectrophotometry, and metabolites were
quantitated by gas chromatography–mass spectrometry. Concentrations
in pigmented and non-pigmented hairs differed significantly for both methamphetamine
(p < 0.01) and amphetamine (p < 0.02), with mean concentration ratios
being 3.69 ± 1.88 and 2.95 ± 1.16 for methamphetamine and amphetamine,
respectively. Segmental analysis indicated that some patients had not been
compliant with medication. We concluded that the incorporation of methamphetamine
and amphetamine into hair of single individuals shows a preference for pigmented
hairs over white hairs and that segmental analysis of hair may be useful
when measuring compliance with medication. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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