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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26, Number 7, October 2002,
pp. 529-531
CASE REPORT: Blood Investigation in a Fatality Involving
the Veterinary Drug T-61
P. Kintz, V. Cirimele, and B. Ludes
Institut de Médecine Légale, Faculté de Medeciné,
11 rue Humann, 67085 Strasbourg, France
A case involving an acute fatality resulting from self-administration
of about 30 mL of T-61, a euthanasia solution, consisting of a mixture of embutramide,
mebezonium, and tetracaine, in a 58-year-old veterinarian is presented. Forensic
investigations consisted of an external body examination, during which 5 mL
of fluorinated femoral blood was collected. Embutramide and tetracaine were
quantitated using gas chromatography coupled to mass spectrometry after extraction
with chloroform/isopropanol/n-heptane (50:17:33, v/v) at pH 9.5 and separation
on an HP5-MS capillary column. Mebezonium was quantitated using liquid chromatography
coupled to mass spectrometry after ion-pair extraction (saturated KI solution)
with methylene chloride at pH 5.4 and separation on a 5-mm Nucleosil C18 column.
Blood concentrations were 43.0, 6.5, and 0.21 mg/L for embutramide, mebezonium,
and tetracaine, respectively. No other drugs, including ethanol, were detected.
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