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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26, Number 4, May/June
pp. 239-243
Case Report: Fatal Overdosage with Nefopam (Acupan®)
A. Tracqui, L. Berthelon, and B. Ludes
Institut de Médecine Légale, Faculté de Médecine
de Strasbourg, 11 rue Humann, 67085 Strasbourg, France
This paper presents a fatality
due to massive, intravenous self-administration of nefopam (Acupan), a non-opiate
central analgesic, in a 37-year-old female. Nefopam was measured in various
postmortem samples by means of high-pressure liquid chromatography coupled to
mass spectrometry via an ionspray interface. Heart blood concentration was 4.38
µg/mL and exceeded by approximately 30 times the highest therapeutic levels
with the usual reservations concerning possible postmortem redistribution. This
is only the third case of death following nefopam overdose reported in the literature. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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