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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26, Number 5, July/August 2002,
pp. 286-296
Tissue Distribution of Difference Mercurial Compounds Analyzed
by the Improved FI-CVAAS
Cheng-Chieh Yen[1],[3], Shing-Hwa Liu[1], Wen-Kang
Chen[3], Ruey-Hseng Lin[4], and Shoei-Yn Lin-Shiau[1],[2]
Institutes of
[1]Toxicology and
[2]Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Departments of
[3]Biochemistry and
[4]Pharmacology, College of Medicine, Chung Shan Medical University, Taichung,
Taiwan
Mercury contents in biological
samples can be measured by cold vapor atomic absorption spectroscopy combined
with the flow-injection analysis system. However, water vapor in the absorption
cell attenuated and distorted the signals. This study described the strategy
to overcome this problem by adding an additional gas–liquid separator after
the mixing/separator assembly. This modification can efficiently minimize the
moisture in the transfer line and in the absorption cell. This improved technique
was adopted to study the differential tissue distribution of methylmercury and
HgS after oral administration to mice for five consecutive days. The present
study suggests that the insoluble HgS (the main constituent of a Chinese mineral
drug, cinnabar, used as a sedative) can still be absorbed from gastrointestinal
tract and distributed to various tissues including the brain. As compared with
methylmercury, the total amount of HgS accumulated in the tissues ranging about
one five-thousandth of methylmercury, which is well correlated with the biological
activity of HgS reported previously. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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