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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26,
Number 1, January/February 2002, pp. 6-10
Quantitation of Organophosphorus Nerve Agent Metabolites
in Human Urine Using Isotope Dilution Gas Chromatography–Tandem Mass Spectrometry
W. Jack Driskell[1], Ming Shih[2], Larry L. Needham[1],
and Dana B. Barr[1]
[1]Centers for Disease Control and Prevention, National Center for Environmental
Health, 4770 Buford Highway NE, Mailstop F-17, Atlanta, Georgia 30341
[2]U.S. Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point
Road, Aberdeen Proving Grounds, Maryland 21069
An isotope dilution gas chromatography–tandem mass spectrometric
(GC–MS–MS) method was developed for quantitating the urinary metabolites
of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine
samples were concentrated by codistillation with acetonitrile, derivatized by
methylation with diazomethane, and analyzed by GC–MS–MS. The limits
of detection were less than 4 µg/L for all the analytes except for the
GA metabolite, which had a limit of detection of less than 20 µg/L.
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