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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 26,
Number 1, January/February 2002, pp. 52-54
CASE REPORT: Distribution of Triazolam and a-Hydroxytriazolam
in a Fatal Intoxication Case
Barry Levine[1],[2], Alison Grieshaber[2], Joseph Pestaner[1],
Karla A. Moore[1], and John E. Smialek[1]
[1]Office of the Chief Medical Examiner, State of Maryland, 111 Penn Street,
Baltimore, Maryland 21201
[2]Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington,
D.C., 20306-6000
The case of a 77-year-old woman who was found dead in her bathtub
with her head clearly above the water line is presented. The decedent had a
medical history of depression, liver disease, spinal stenosis, and diabetes
mellitus. An empty medication bottle of triazolam was found in the trashcan.
At autopsy, no injury or evidence of drowning was found. Toxicological analysis
identified triazolam at a concentration of 0.12 mg/L in the heart blood. Triazolam
and a-hydroxytriazolam were quantitated in the specimens received. The medical
examiner ruled that the cause of death was triazolam intoxication and the manner
of death was suicide.
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