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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 25,
Number 2, March 2001, pp. 99-105
Analysis of Amphetamine and Congeners in Illicit Samples
by Liquid Chromatography and Capillary Electrophoresis
Anna
Maria Di Pietra[1], Roberto Gotti[1], Elia Del Borrello[2], Romeo Pomponio[1],
and Vanni Cavrini[1]
[1]Dipartimento di Scienze Farmaceutiche, Università di Bologna, Via
Belmeloro 6, 40126 Bologna, Italy and
[2]Dipartimento di Medicina e Sanità Pubblica—Sezione di Medicina
Legale, Università di Bologna, Italy
Screening
methods based on liquid chromatography (HPLC) and capillary electrophoresis
(CE) have been developed for the identification and determination of amphetamine,
methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine,
and 3,4-methylenedioxyethylamphetamine in illicit tablets. Diethylpropione,
(–)-ephedrine, and 3-amino-1-phenylbutane were also included in the study
as amphetamino-related compounds. The HPLC–diode-array detection method
involved on-line photochemical derivatization to enhance the selectivity of
detection allowing amphetamines to be distinguished from related compounds such
as diethylpropione (amfepramone). When the CE approach was adopted, two identification
parameters (UV spectra and migration index) were used and the enantioresolution
of the racemic amphetamines was achieved using hydroxypropyl-b-cyclodextrin
as chiral selector. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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