Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection

6600 W. Touhy Ave.
Niles, IL 60714
Tel: 847.647.2900
Fax: 847.647.1155
circulation@jatox.com

Published: Journal of Analytical Toxicology, ISSN 0146-4760, Volume 25, Number 2, March 2001, pp. 81-87

Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection
Margaret A. McCooeye, Barbara Ells, David A. Barnett, Randy W. Purves, and Roger Guevremont*
Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

Reproduction of editorial content of this journal is prohibited without publisher’s permission.

This article is available in its entirety by fax for $40.00 each.
Visa, MasterCard and AMEX accepted.

To order electronically click here
or call: 847-647-2900 ext. 1323
or fax request to: 847-647-1155.

To order multiple copies click here.

Please indicate JAT volume and issue along with page numbers.