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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 25, Number 5, July/August, pp. 323-326
Comparison of HPLC and GC–MS Methods for Determination
of Embutramide (A Component of Tanax® or T-61®) in Biological Specimens
M. Giorgi,
S. Bertini, G. Soldani, and M. Giusiani
1Section of Pharmacology and Toxicology, Department of Veterinary Clinics,
University of Pisa, V.le delle Piagge 2, 56124 Pisa, Italy; 2Institute of Food
Inspection, University of Parma, V. del Taglio 8, 43100, Parma, Italy; and 3Section
of Forensic Medicine and Toxicology, Department of Public Health, University
of Pisa, V. Roma 55, 56100 Pisa, Italy
Tanax or T-61, a euthanasia solution commonly used in veterinary
medicine, has been often involved in suicide attempts (humans) and malicious
intoxications (animals). For forensic reasons, the identification of one or
more of the three components (embutramide, mebenzonium iodide, and tetracaine
hydrochloride) of Tanax is needed to confirm the hypothesis of intoxication.
This study was performed with new high-performance liquid chromatographic and
gas chromatographic–mass spectrometric methods to identify embutramide
in biological matrices (blood, liver, kidney) from different animal species.
The good sensitivity and specificity of both methods recommend their use in
toxicological analysis in both human and veterinary medicine.
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