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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 25,
Number 3, April 2001, pp. 190-197
Qualitative
Screening for Drugs of Abuse in Hair Using GC–MS
Susan Paterson,
Neil McLachlan-Troup, Rosa Cordero, Martin Dohnal, and Suzannah Carman
Toxicology Unit, Imperial College School of Medicine, St. Dunstan’s Road,
London, United Kingdom, W6 8RP
A previously described method for the analysis of hair has been
modified to include analysis for amphetamines, benzodiazepines, cocaine and
its metabolites, methadone and its metabolite, and phencyclidine in addition
to opiates on a sample of hair. The samples of hair were washed twice with dichloromethane
and cut into 1-mm segments prior to extraction with methanol at 45°C for
18 h. The extracts were split into two parts; both were evaporated to dryness.
One half of the extract was derivatized using MBTFA for analysis of amphetamines,
and the other half was derivatized using MTBSTFA for analysis of the remaining
drugs. The extracts were analyzed using electron impact gas chromatography–mass
spectrometry operating in selected ion monitoring mode. In total, 18 drugs of
abuse/metabolites could be detected. The method was used to screen 20 hair samples
from patients attending a methadone-maintenance clinic.
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