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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 24,
Number 7, October,
pp. 567-571
Here is where the title stuff goes
Loss
of THCCOOH from Urine Specimens Stored in Polypropylene and Polyethylene Containers
at Different Temperatures
Peter
R. Stout, Carl K. Horn, and David R. Lesser
Navy Drug Screening Laboratory, P.O. Box 113, Bldg. H-2033, Naval Air Station,
Jacksonville, Florida 32212
The loss of
D9-tetrahydrocannabinol (THCCOOH) from urine specimens
stored in polypropylene and polyethylene containers at 4°C and 25°C
was examined. All specimens were analyzed by GC–MS after sampling at various
times over a one-week period. Data were analyzed by one-way analysis of variance
and fitted with a first order kinetic equation. Rapid loss of THCCOOH was seen
at 4°C for both polypropylene (14% maximal loss, t1Ú2 = 0.53 min) and polyethylene
(17% maximal loss, t1Ú2 = 5.77 min) bottles. At 25°C, a small loss (<
5%) was observed in polypropylene and no significant loss was seen for urine
in polyethylene. All losses stabilized within 1 h, and no further losses were
seen over one week. The results indicate that THCCOOH binding may be due to
decreased solubility of THCCOOH at lower temperatures and subsequent association
of THCCOOH with the more lipophilic plastic. The results also indicate that
polypropylene and polyethylene do not bind THCCOOH to such an extent as to compromise
the integrity of specimens.
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