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Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 24,
Number 8, November/December,
pp. 691-695
Determination of
(+)- and (–)-Bromoisovalerylurea in Sera of Overdosed Subjects
Takashi
Nishikawa1,*, Yoshito Kamijo2, Rumiko Kondo2, Hideaki Sugie3, Katsuyoshi Kurihara3,
Takanori Okuda4,
Naoto Matsumoto5, Yoshiaki Okada5, and Hideki Ohtani1
Departments of 1Clinical Pathology, 2Emergency and Critical Care Medicine, and
3Legal Medicine, Kitasato University School of Medicine, 1-15-1, Kitasato, Sagamihara,
Kanagawa, Japan; 4Poison Center in Kenwakai Otemachi Hospital, 15-1, Otemachi,
Kokura-Kita, Kitakyusyu, Japan; and 5National Defense Medical College Hospital,
3-2, Namiki, Saitama, Japan
Bromoisovalerylurea (bromisovalum) is a sedative-hypnotic
given orally as a racemic mixture of optical isomers (i.e., (+)- and (–)-enantiomer)
and frequently taken in overdose in order to commit suicide. Sera from 16 overdosed
subjects were analyzed for each enantiomer by high-performance liquid chromatography
on chiral stationary phases. The (+)-enantiomer concentration was lower than
the (–)-enantiomer concentration in all specimens, that is, the ratio of
the (+)-enantiomer to the total concentration ranged from about 50% to 0%. The
ratio of the (+)-enantiomer was continuously decreasing in each subject. The
data indicate that the drug in gastrointestinal tract was absorbed into blood
nonstereoselectively and that the drug in blood was eliminated stereoselectively.
The enantioselective determination of this drug will give useful information
on absorption and elimination. Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
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