| |
Published:
Journal of Analytical Toxicology,
ISSN 0146-4760,
Volume 24,
Number 4, May/June 2000, pp. 250-256
The
Use of Low-Resolution FT-IR Spectrometry for the Analysis of Alcohols in Breath Fast
and reliable diagnostic methods are needed for detection or exclusion of industrial
solvents as a cause of intoxication. Analyzing human breath reveals the presence
of any volatile substance. A portable Fourier transform infrared (FT-IR) multicomponent
point-of-care analyzer was developed for exhaled breath. The analyzer proved
to be accurate and precise in laboratory tests for simultaneous measurement
of methanol and ethanol in water. Ethanol, in addition to normal contents of
breath, was simultaneously analyzed in human experiments, and the results correlated
well with blood samples. FT-IR method has a traceable calibration to physical
properties of the analyte. The measured spectra can also be saved and analyzed
later. Breath analysis with FT-IR is fast and easy, and no preparation of the
sample is needed.Olli
Laakso1,*, Matti Haapala2, Petri Jaakkola3, Reijo Laaksonen4,5, Janne Nieminen2,
Mika Pettersson2, Markku Räsänen2, and Jaakko-Juhani Himberg6
1Department of Anesthesiology, Helsinki University Central Hospital, P.O. Box
260, 00029 HUS, Finland; 2Laboratory of Physical Chemistry, University of Helsinki,
P.O. Box 55, 00014 Helsingin Yliopisto, Finland; 3Temet Instruments Oy, Asentajankatu
3, 00810 Helsinki, Finland; 4Department of Clinical Pharmacology, University of
Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland; 5Department of Medicine,
Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland; and 6HUCH
Laboratory Diagnostics, Section of Clinical Chemistry, Hematology, and Clinical
Pharmacology, P.O. Box 140, 00029 HUS, Finland Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
This
article is available in its entirety by fax for $40.00 each.
Visa, MasterCard and AMEX accepted.
To
order electronically click here
or call: 847-647-2900 ext. 1323
or fax request to: 847-647-1155.
To order multiple copies click here.
Please indicate JAT
volume and issue along with page numbers. |
|
Home | Subscribe
| Current Issue | Back Issues
| Search | Advertise | Other Publications
| |
