Interference in the Quantitation of Methylated Arsenic Species in Human Urine

Published: Journal of Analytical Toxicology, Volume 24, Number 1, January/February, pp.8-10

Elimination Half-Life of Acetone in Humans: Case Reports and Review of the Literature
A. W. Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linköping, Sweden

Two instances of finding abnormally high concentrations of acetone in urine (0.10 g/dL and 0.052 g/dL) without any measurable amounts of ethanol (< 0.005 g/dL) or isopropanol (< 0.005 g/dL) prompted a survey of the elimination kinetics of isopropanol and its metabolite acetone in humans. In a hospital patient who had ingested denatured alcohol, the elimination half-life (t1/2) of acetone during detoxification was 27 h and not 3–5 h as reported by other workers. Several other literature reports of individuals who had ingested isopropanol as well as controlled studies after administration of moderate amounts of acetone and/or isopropanol support the notion of a long elimination half-life of 17–27 h for acetone compared with a t1/2 of 1–3 h for isopropanol.

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