Published: Journal of Analytical Toxicology, Volume 24, Number 1, January/February, pp.27-31
Elimination of the Interferences by Keto-Opiates in
the GC–MS Analysis of 6-Monoacetylmorphine
Jasbir Singh, Renee
E. Burke, and Linda E. Mertens
Veterans Affairs
Medical Center, Laboratory Service (113), One Veterans Drive, Minneapolis, Minnesota
55417
A simple procedure to eliminate the interference from keto-opiates in the analysis of 6-monoacetylmorphine (6-MAM) by gas chromatography–mass spectrometry is described. The pretreatment of urine samples with sodium bisulfite followed by solid-phase extraction results in the elimination of the bisulfite addition products formed from the reaction of the bisulfite ions with the carbonyl carbon of the keto-opiates. This simple procedure results in the accurate quantitation of 6-MAM at a concentration of 4 ng/mL in the presence of keto-opiates up to 10,000 ng/mL.
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