Published: Journal of Analytical Toxicology, Volume 24, Number 1, January/February, pp.17-21
Structural Elucidation of an Uncommon Phenylethylamine Analogue
in Urine Responsible for Discordant Amphetamine Immunoassay Results
C. Marson, S. Schneider,
F. Meys, and R. Wennig
Laboratoire National
de Santé, Division de Toxicologie, Centre Universitaire de Luxembourg,
L-1511 Luxembourg
The present paper describes investigations following the analysis of a urine specimen containing important amounts of an unknown substance detected by gas chromatography–mass spectrometry (GC–MS) analysis. FPIA analysis was positive (cutoff 0.3 mg/L) and Triage™ 8 rapid test was negative (cutoff 1 mg/L) for amphetamines. Considering the GC–MS spectrum, two different molecules, for example, N-ethyl-1-(3,4-methylenedioxyphenyl)ethylamine (1) or N-ethyl-4-methoxyamphetamine (2), have been suspected. Synthesis of these two compounds was carried out together with spectral (MS, 1H and 13C NMR, IR, UV) and chromatographic (GC) characterization as well as determination of immunological cross reactivities (FPIA and Triage 8). The unknown compound present in the urine specimen has been finally identified as N-ethyl-4-methoxyamphetamine (2), an uncommon amphetamine analogue.
Reproduction of editorial content of this journal is prohibited without publisher’s permission.
| This article is available in its entirety by fax for $40.00 each. Visa, MasterCard and AMEX accepted. To order electronically click
here Please indicate JAT volume and issue along with page numbers. |
| Home | Subscribe | Current Issue | Back Issues | Search | Advertise | Other Publications | Site Map |