Published: Journal of Analytical Toxicology, Volume 24, Number 3, April, pp.157-164
Acute
Metobromuron Poisoning with Severe Associated Methemoglobinemia. Identification
of Four Metabolites in Plasma and Urine by LC–DAD, LC–ESI-MS, and
LC–ESI-MS–MS
Laboratoire de Pharmacologie-Toxicologie, CHU,
4 rue Larrey, 49033 Angers, France
Centre Anti-Poison, CHU, Angers, France
Anne
Renault
Réanimation Médicale, CHU, Brest, France
A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appeared at day 4 and decreased slowly to day 12. Metobromuron was analyzed by liquid chromatography with diode-array detection. Initial plasma concentration and elimination half-life were 4.9 mg/L and 5 h, respectively. Several metabolites were also detected, and four of those were identified by liquid chromatography–electrospray mass spectrometry. Normetobromuron, bromophenylurea, and bromoacetanilide were detected in plasma, but only N-methyl bromophenylurea was detected in urine. Bromoacetanilide probably results from acetylation of the intermediate bromoaniline. Methemoglobinemia could result from metabolization of metobromuron to bromoaniline and bromoacetanilide.
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