Published: Journal of Analytical Toxicology, Volume 23, Number 3, May/June 1999, pp.173-176.
Procainamide Inhibition of Human Hepatic Degradation of
Cocaine and Cocaethylene In Vitro
Procainamide (PA), a cardioactive drug, inhibited the degradation of both cocaine (COC) and cocaethylene (CE) when either was incubated in human liver homogenates for 3 h at 37°C. PA appeared to enhance the formation of CE when COC and ethanol (ETOH) were incubated together in liver homogenate. These observations are clinically significant because cardiotoxicity is common after COC abuse and because PA may be administered to individuals who use COC alone and with ETOH.
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