Published: Journal of Analytical Toxicology, Volume
23,
Number 4, July/August
1999, pp.290-293 .
A Case of Aldicarb Poisoning: A Possible Murder Attempt
A. Covaci, P. Manirakiza, V. Coucke, R. Beckers, Ph.G. Jorens, and P. Schepens
A couple showing signs of cholinergic crisis was admitted to the hospital. Analyses
with high-performance liquid chromatography and gas chromatography–mass spectrometry
conducted on serum, urine, and stomach contents that were collected few hours
after first symptoms showed the presence of aldicarb, which is the most potent
carbamate insecticide on the market. A murder attempt was suspected because the
patients showed the first signs some minutes after drinking coffee upon returning
home and no commercial products containing aldicarb were found in the house. Because
of the reversibility of inhibition of acetylcholinesterase, the patients recovered
after treatment with atropine and toxogonin. They left the hospital after 12 days.
To our knowledge, the serum concentrations of aldicarb reported in this paper
are the highest reported for a nonfatal case.
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