Determination of Pyrolysis Products of Smoked Methamphetamine Mixed with ...

Published: Journal of Analytical Toxicology, Volume 23, Number 1, January/February 1999, pp. 41-45.

Determination of Pyrolysis Products of Smoked Methamphetamine Mixed with Tobacco by Tandem Mass Spectrometry
Maw-Rong Lee, Jsuey Jeng, Wei-Shin Hsiang, and Bao-Huey Hwang

This study examines the pyrolysis products of smoked methamphetamine mixed with tobacco that was trapped with a C₈ adsorbent cartridge and then detected by gas chromatography– tandem mass spectrometry. According to the results, the mainstream smoke contains 2-methylpropyl-benzene, 2-chloropropyl-benzene, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 3-ethyl-phenol, methamphetamine, dimethylamphetamine, hydroquinone, 3-methyl-5-(1-methylethyl)-methylcarbamate phenol, N-methyl-N-(2-phenylethyl)-acetamide, 4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-2-cyclohexene-1-one, propanoic acid, N-acetylmethamphetamine, phenyl ester, and furfurylmethylamphetamine. In addition, the compounds in sidestream smoke are 2-propenyl benzene, phenylacetone, methamphetamine, dimethylamphetamine, benzyl methyl ketoxime, 3,4-dihydro-2-naphthalenone, N-folmyamphetamine, N-acetylamphetamine, bibenzyl, N-folmylmethamphetamine,
N-acetylmethamphetamine, N-propionymethamphetamine, and furfurylmethylamphetamine. Moreover, the presence of methamphetamine promotes the oxidation of the tobacco components.

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