Published: Journal of Analytical Toxicology, Volume 22, Number 5, September 1998, pp. 383–388.
Identification of Metabolites of Nerve
Agent VX in Serum Collected from a Victim
Hitoshi Tsuchihashi, Munehiro
Katagi, Mayumi Nishikawa, and Michiaki Tatsuno
A human serum sample collected from a victim of the Osaka VX incident was analyzed according to our developed technique for metabolites of VX. Gas chromatography–mass spectrometry (GC–MS) in full-scan electron impact and chemical ionization modes were used, and, for more reliable confirmation, GC–MS–MS was also employed. In the serum sample, both ethyl methylphosphonic acid and 2-(diisopropylamino-ethyl)methyl sulfide were detected. These results indicated that the techniques using GC–MS and GC–MS–MS were applicable to biological samples such as serum. These results also provide the first documented, unequivocal identification of the specific metabolites of VX in victim’s serum and, furthermore, clarify a part of the metabolic pathway of VX in the human body.
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