Published: Journal of Analytical Toxicology, Volume 22, Number 7, November/December 1998, pp. 549-558.
Determination of Common Drugs of Abuse in Body Fluids Using
One Isolation Procedure and Liquid Chromatography–Atmospheric-Pressure
Chemical-Ionization Mass Spectrometry
Maciej J. Bogusz , Rolf-Dieter Maier, Klaus-Dieter Krüger,
and Ulrike Kohls
A method for determining opiate agonists (morphine, morphine-3-glucuronide, morphine-6-glucuronide, 6-monoacetylmorphine, codeine, codeine-6-glucuronide, dihydrocodeine, dihydromorphine, buprenorphine, methadone, tramadol, and ibogaine), cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) and lysergic acid diethylamide in serum, blood, urine and other biological matrices is presented. Aliquots (0.5–1.5 mL) of biological fluids were spiked with appropriate deuterated internal standards and extracted using a common solid-phase extraction method (C18 cartridges). The extracts were subjected to liquid chromatographic–atmospheric-pressure chemical-ionization mass spectrometric examination using selected ion monitoring procedures. These procedures were developed after analysis of full-scan mass spectra of examined compounds. The extraction method appeared very universal; the recoveries were high for almost all drugs and the extracts were very clean. The procedure was applied for routine forensic casework.
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