Published: Journal of Analytical Toxicology, Volume 22, Number 1, January/February 1998, pp. 55–60.
Identification of New
Urinary Metabolites of Famprofazone in Humans
H.-S. Shin,
B.-B. Park, S.N. Choi, J.J. Oh, C.P. Hong, and H. Ryu
Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography–mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methyl-bis-trifluoroacetamide (MBTFA) and N-methyl-N-trimethyl silyl trifluoroacetamide (MSTFA). Famprofazone was rapidly and extensively metabolized by N-dealkylation, b-hydroxylation, and p-hydroxylation. The major metabolite, representing approximately 15% of the dose, was methamphetamine. The other metabolites, which were present in minor amounts, were amphetamine, norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, p-hydroxyamphetamine, p-hydroxymethamphetamine, and p-hydroxy-demethyl famprofazone.
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