Published: Journal of Analytical Toxicology, Volume 21, Number 2, March/April 1997, pp. 166–169.
CASE REPORT:
Comparison
of Analytical Methods in the Determination of Two Venlafaxine
Fatalities
C. Long, J.
Crifasi, D. Maginn, M. Graham, and S. Teas
Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC–NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 µg/mL venlafaxine and 5.03 µg/mL O-desmethylvenlafaxine, and Case 2 had 89.67 µg/mL venlafaxine with 3.44 µg/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.
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