Published: Journal of Analytical Toxicology, Volume 21, Number 4, July/August 1997, pp. 249–251.
Verification of
Exposure to Sulfur Mustard in Two Casualties of the
Iran–Iraq Conflict
H.P. Benschop, G.P. van der
Schans, D. Noort, A. Fidder, R.H. Mars-Groenendijk, and L.P.A. de
Jong
The exposure of two Iranian victims of the Iran–Iraq conflict (1980–1988) to sulfur mustard was established by immunochemical and mass spectrometric analysis of blood samples taken 22 and 26 days after the alleged exposure. One victim suffered from skin injuries compatible with sulfur mustard intoxication but did not have lung injuries; the symptoms of the other victim were only vaguely compatible with sulfur mustard intoxication. Both patients recovered. Immunochemical analysis was based on detection of the N7-guanine adduct of the agent in DNA from lymphocytes and granulocytes, whereas the N-terminal valine adduct in globin was determined by gas chromatography–mass spectrometry after a modified Edman degradation. The valine adduct levels correspond with those found in human blood after in vitro treatment with 0.9µM sulfur mustard.
Reproduction of editorial content of this journal is prohibited without publisher’s permission.
| This article is available in its entirety by fax for $40.00 each. Visa, MasterCard and AMEX accepted. To order electronically click
here Please indicate JAT volume and issue along with page numbers. |
| Subscribe | Current Issue | Back Issues | Search | Advertise | Other Publications |