Published: Journal of Analytical Toxicology, Volume 21, Number 1, January/February 1997, pp. 36–40.
A Simple and Sensitive Quantitation of N,N-Dimethyltryptamine
by Gas Chromatography with Surface Ionization Detection
A. Ishii, H. Seno, O. Suzuki, H. Hattori, and T. Kumazawa
A simple and sensitive method for determination of N,N-dimethyltryptamine (DMT) by gas chromatography (GC) with surface ionization detection (SID) is presented. Whole blood or urine, containing DMT and gramine (internal standard), was subjected to solid-phase extraction with a Sep-Pak C18 cartridge before analysis by GC–SID. The calibration curve was linear in the DMT range of 1.25–20 ng/mL blood or urine. The detection limit of DMT was about 0.5 ng/mL (10 pg on-column). The recovery of both DMT and gramine spiked in biological fluids was above 86%.
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