Published: Journal of Analytical Toxicology, Volume 21, Number 1, January/February 1997, pp. 54–58.
Simple Extractive Derivatization of
Methamphetamine and its Metabolites in Biological Materials with
Extrelut® Columns for their GC–MS
Determination
K. Hara, S. Kashimura, Y.
Hieda, and M. Kageura
A simple, extractive heptafluoro-n-butyrylation with Extrelut columns was devised to simultaneously measure methamphetamine (MAMP), amphetamine (AMP), 4-hydroxymethamphetamine (HMAMP), and 4-hydroxyamphetamine (HAMP) in biological materials by gas chromatography–mass spectrometry (GC–MS) using 4-methoxymethamphetamine-d5 as the internal standard. Human urine, human whole blood, and porcine skeletal muscle spiked with the stimulant standards were used for evaluating the method. After deproteinization and adjustment of the pH to 12.6, the sample was applied to an Extrelut column. Using the present method, AMP, MAMP, and HMAMP could be determined in an actual forensic case study.
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